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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 37 Issue 2
Mar.  2023
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Solomon E. Owumi, Uche O. Arunsi, Moses T. Otunla, Imisioluwa O. Oluwasuji. Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats[J]. The Journal of Biomedical Research, 2023, 37(2): 100-114. DOI: 10.7555/JBR.36.20220108
Citation: Solomon E. Owumi, Uche O. Arunsi, Moses T. Otunla, Imisioluwa O. Oluwasuji. Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats[J]. The Journal of Biomedical Research, 2023, 37(2): 100-114. DOI: 10.7555/JBR.36.20220108
shu

Exposure to lead and dietary furan intake aggravates hypothalamus-pituitary-testicular axis toxicity in chronic experimental rats

  • 1.

    Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State 200004, Nigeria

  • 2.

    Department of Cancer Immunology and Biotechnology, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK

More Information
  • Corresponding author:

    Solomon E. Owumi, ChangeLab, Changing Live, Room NB 302, Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Odeziaku Road, Ibadan, Oyo State 200004, Nigeria. Tel: +234-806-951-3033. E-mail: owumisa@hotmail.com

  • Received Date: May 10, 2022
  • Revised Date: June 17, 2022
  • Accepted Date: August 03, 2022
  • Available Online: September 27, 2022
    Abstract
  • Lead (Pb) and furan are toxic agents, and persistent exposure may impair human and animal reproductive function. We therefore explored the effects of Pb and furan on male rat hypothalamic-pituitary-gonadal reproductive status, oxidative stress, inflammation, and genomic integrity. We found that co-exposure to Pb and furan reduced the activities of testicular function enzymes, endogenous antioxidant levels, total sulfhydryl group, and glutathione. Sperm abnormality, biomarkers of oxidative stress, inflammation, and p53 expression were increased in a dose-dependent manner by treatment with furan and Pb. Typical rat gonad histoarchitecture features were also damaged. Conclusively, co-exposure to Pb and furan induced male reproductive function derangement by decreasing the antioxidant defences in rats, increasing abnormalities in spermatozoa morphology, and reducing reproductive hormone in circulation. These pathophysiological alterations, if persistent, might provide a permissive environment for potentiating reproductive dysfunction and infertility.
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  • CLC number: X592; R114, Document code: A

    The authors reported no conflict of interests.

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    Imisioluwa O. Oluwasuji
    • 1.

      Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Oyo State 200004, Nigeria

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