3.8

CiteScore

2.4

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 6
Oct.  2017
Turn off MathJax
Article Contents
Abstract
Related Articles
Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati. Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats[J]. The Journal of Biomedical Research, 2017, 31(6): 521-527. DOI: 10.7555/JBR.31.20160151
Citation: Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati. Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats[J]. The Journal of Biomedical Research, 2017, 31(6): 521-527. DOI: 10.7555/JBR.31.20160151
shu

Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats

  • 1.

    Department of Physiology, Faculty of Medicine

  • 2.

    Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran

  • 3.

    Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran

  • 4.

    Departments of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran

  • 5.

    Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

More Information
  • Received Date: November 15, 2016
  • Revised Date: December 19, 2016
    Abstract
  • Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats were divided into the control group, the ethanol group, and the ethanol plus ginger extract group. Six weeks of ethanol treatment increased the proliferation of lung cells, and induced fibrosis, inflammation and leukocyte infiltration. A significant rise in the level of 8- hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein was also observed. Ginger extract significantly ameliorated the above changes. These findings indicate that ethanol induces abnormalities in the lungs by oxidative DNA damage and oxidative stress, and that these effects can be alleviated by ginger, which may function as an antioxidant and anti-inflammatory agent.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]Qian Gu, Qin Wang, Rui Hua, Wenhao Zhang, Jianzhen Teng, Jiazheng Ma, Zhou Dong, Xiaoxuan Gong, Chunjian Li. Low RBC counts predict high on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention and treated with clopidogrel[J]. The Journal of Biomedical Research, 2024, 38(1): 87-91. DOI: 10.7555/JBR.37.20230035
    [2]Yao Daokuo, Gao Xiangyu, Zhao Huiqiang, Chen Hui, Wang Lexin. Multivessel coronary artery ectasia and severe calcification in a patient with pheochromocytoma: a case report[J]. The Journal of Biomedical Research, 2019, 33(1): 69-72. DOI: 10.7555/JBR.32.20170047
    [3]Mingming Gao, Guo Xin, Xu Qiu, Yuhui Wang, George Liu. Establishment of a rat model with diet-induced coronary atherosclerosis[J]. The Journal of Biomedical Research, 2017, 31(1): 47-55. DOI: 10.7555/JBR.31.20160020
    [4]Jiawei Liao, Wei Huang, George Liu. Animal models of coronary heart disease[J]. The Journal of Biomedical Research, 2017, 31(1): 3-10. DOI: 10.7555/JBR.30.20150051
    [5]Rajiv Shrestha, Jing Xu, Dujiang Xie, Zhizhong Liu, Tian Xu, Fei Ye, Shiqing Din, Xuesong Qian, Song Yang, Yueqiang Liu, Feng Li, Aiping Zhang, Shaoliang Chen. Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease: a multi-center retrospective analysis of 4,334 patients[J]. The Journal of Biomedical Research, 2014, 28(5): 368-375. DOI: 10.7555/JBR.28.20120127
    [6]Xuezhong Wang, Xiaoxuan Gong, Tiantian Zhu, Qiu Zhang, Yangyang Zhang, Xiaowei Wang, Zhijian Yang, Chunjian Li. Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery[J]. The Journal of Biomedical Research, 2014, 28(2): 108-113. DOI: 10.7555/JBR.28.20120139
    [7]Min Zhang, Huiwei He, Ze-Mu Wang, Zhihui Xu, Ningtian Zhou, Zhengxian Tao, Bo Chen, Chunjian Li, Tiebing Zhu, Di Yang, Liansheng Wang, Zhijian Yang. Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury: a prospective, single-center and double-blind study[J]. The Journal of Biomedical Research, 2014, 28(2): 98-107. DOI: 10.7555/JBR.28.20130124
    [8]Marina Piccinelli, Ernest Garcia. Multimodality image fusion for diagnosing coronary artery disease[J]. The Journal of Biomedical Research, 2013, 27(6): 439-451. DOI: 10.7555/JBR.27.20130138
    [9]Fang Cui, Yusheng Ren, Heng Jin, Bo Cui. Rehabilitation training improves exercise tolerance after percutaneous coronary intervention[J]. The Journal of Biomedical Research, 2012, 26(4): 248-252. DOI: 10.7555/JBR.26.20110119
    [10]Chunjian Li, Zhijian Yang, Kejiang Cao. Retrieval of dislodged coronary stent from left renal artery by gooseneck snare[J]. The Journal of Biomedical Research, 2010, 24(6): 479-482. DOI: 10.1016/S1674-8301(10)60064-4

  • Cited by

    Periodical cited type(15)

    1. Arsh H, Manoj Kumar F, Simran F, et al. Role of PCSK9 inhibition during the inflammatory stage of SARS-COV-2: an updated review. Ann Med Surg (Lond), 2024, 86(2): 899-908. DOI:10.1097/MS9.0000000000001601
    2. Saputri FC, Azmi NU, Puteri MU, et al. High-Fat Diet Enhances Platelet Activation and Is Associated with Proprotein Convertase Subtilisin Kexin 9: An Animal Study. Nutrients, 2023, 15(20): 4463. DOI:10.3390/nu15204463
    3. Ishikawa H, Nagashima R, Kuno Y, et al. Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice. Diabetes Metab Syndr Obes, 2023, 16: 2855-2864. DOI:10.2147/DMSO.S428190
    4. Chen PW, Tseng SY, Chang HY, et al. Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity. Int J Mol Sci, 2022, 23(17): 9768. DOI:10.3390/ijms23179768
    5. Ayoub C, Azar Y, Maddah D, et al. Low circulating PCSK9 levels in LPL homozygous children with chylomicronemia syndrome in a syrian refugee family in Lebanon. Front Genet, 2022, 13: 961028. DOI:10.3389/fgene.2022.961028
    6. Bouchard J, Malalgoda M, Storsley J, et al. Health Benefits of Cereal Grain- and Pulse-Derived Proteins. Molecules, 2022, 27(12): 3746. DOI:10.3390/molecules27123746
    7. Majeed ML, Ghafil FA, Fatima G, et al. Anti-Atherosclerotic and Anti-Inflammatory Effects of Curcumin on Hypercholesterolemic Male Rabbits. Indian J Clin Biochem, 2021, 36(1): 74-80. DOI:10.1007/s12291-019-00858-5
    8. Fedoryak O, Arama C, Diarra I, et al. Association of the rs562556 PCSK9 Gene Polymorphism with Reduced Mortality in Severe Malaria among Malian Children. Can J Infect Dis Med Microbiol, 2020, 2020: 9340480. DOI:10.1155/2020/9340480
    9. Drouin-Chartier JP, Tremblay AJ, Hogue JC, et al. Plasma PCSK9 correlates with apoB-48-containing triglyceride-rich lipoprotein production in men with insulin resistance. J Lipid Res, 2018, 59(8): 1501-1509. DOI:10.1194/jlr.M086264
    10. Chan DC, Watts GF, Somaratne R, et al. Comparative Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibition and Statins on Postprandial Triglyceride-Rich Lipoprotein Metabolism. Arterioscler Thromb Vasc Biol, 2018, 38(7): 1644-1655. DOI:10.1161/ATVBAHA.118.310882
    11. Eroğlu Z, Tetik Vardarlı A, Düzgün Z, et al. Case-control study on PCSK9 R496W (rs374603772) and D374Y (rs137852912) mutations in Turkish patients with primary dyslipidemia. Anatol J Cardiol, 2018, 19(5): 334-340. DOI:10.14744/AnatolJCardiol.2018.86648
    12. Hedayat AF, Park KH, Kwon TG, et al. Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model. Transl Res, 2018, 192: 30-45. DOI:10.1016/j.trsl.2017.10.007
    13. Chen IC, Tseng WK, Li YH, et al. Effect of cilostazol on plasma levels of proprotein convertase subtilisin/kexin type 9. Oncotarget, 2017, 8(64): 108042-108053. DOI:10.18632/oncotarget.22448
    14. Zhang PY. PCSK9 as a therapeutic target for cardiovascular disease. Exp Ther Med, 2017, 13(3): 810-814. DOI:10.3892/etm.2017.4055
    15. Yu Z, Huang T, Zheng Y, et al. PCSK9 variant, long-chain n-3 PUFAs, and risk of nonfatal myocardial infarction in Costa Rican Hispanics. Am J Clin Nutr, 2017, 105(5): 1198-1203. DOI:10.3945/ajcn.116.148106

    Other cited types(0)

Catalog

    Elaheh Heshmati
    • 5.

      Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

    1. On this Site
    2. On Google Scholar
    3. On PubMed
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2740) PDF downloads (247) Cited by(15)
    Related

    ©2025 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return