4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 6
Oct.  2017
Turn off MathJax
Article Contents
Abstract
Related Articles
Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati. Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats[J]. The Journal of Biomedical Research, 2017, 31(6): 521-527. DOI: 10.7555/JBR.31.20160151
Citation: Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati. Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats[J]. The Journal of Biomedical Research, 2017, 31(6): 521-527. DOI: 10.7555/JBR.31.20160151
shu

Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats

  • 1.

    Department of Physiology, Faculty of Medicine

  • 2.

    Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran

  • 3.

    Nephrology and Kidney Transplant Research Center, Urmia University of Medical Sciences, Urmia, Iran

  • 4.

    Departments of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran

  • 5.

    Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

More Information
  • Received Date: November 15, 2016
  • Revised Date: December 19, 2016
    Graphical Abstract
    • Abstract
  • Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats were divided into the control group, the ethanol group, and the ethanol plus ginger extract group. Six weeks of ethanol treatment increased the proliferation of lung cells, and induced fibrosis, inflammation and leukocyte infiltration. A significant rise in the level of 8- hydroxydeoxyguanosine, NADPH oxidase, and oxidized low-density lipoprotein was also observed. Ginger extract significantly ameliorated the above changes. These findings indicate that ethanol induces abnormalities in the lungs by oxidative DNA damage and oxidative stress, and that these effects can be alleviated by ginger, which may function as an antioxidant and anti-inflammatory agent.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]Izzatullo Ziyoyiddin o`g`li Abdullaev, Ulugbek Gapparjanovich Gayibov, Sirojiddin Zoirovich Omonturdiev, Sobirova Fotima Azamjonovna, Sabina Narimanovna Gayibova, Takhir Fatikhovich Aripov. Molecular pathways in cardiovascular disease under hypoxia: Mechanisms, biomarkers, and therapeutic targets[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240387
    [2]Gelena Kakurina, Marina Stakheeva, Elena Sereda, Evgenia Sidenko, Olga Cheremisina, Evgeny Choinzonov, Irina Kondakova. A pilot study of the relative number of circulating tumor cells and leukocytes containing actin-binding proteins in head and neck cancer patients[J]. The Journal of Biomedical Research, 2023, 37(3): 213-224. DOI: 10.7555/JBR.36.20220182
    [3]Liu Xiaowei, Nakamura Fumihiko. Mechanotransduction, nanotechnology, and nanomedicine[J]. The Journal of Biomedical Research, 2021, 35(4): 284-293. DOI: 10.7555/JBR.34.20200063
    [4]Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
    [5]Vetrivel Preethi, Kim Seong Min, Saralamma Venu Venkatarame Gowda, Ha Sang Eun, Kim Eun Hee, Min Tae Sun, Kim Gon Sup. Function of flavonoids on different types of programmed cell death and its mechanism: a review[J]. The Journal of Biomedical Research, 2019, 33(6): 363-370. DOI: 10.7555/JBR.33.20180126
    [6]Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023
    [7]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [8]Liangtao Zhao, Baobao Cai, Zipeng Lu, Lei Tian, Song Guo, Pengfei Wu, Dong Qian, Qingcheng Xu, Kuirong Jiang, Yi Miao. Modified methods for isolation of pancreatic stellate cells from human and rodent pancreas[J]. The Journal of Biomedical Research, 2016, 30(6): 510-516. DOI: 10.7555/JBR.30.20160033
    [9]Ming-Hai Wang, Ruiwen Zhang, Yong-Qing Zhou, Hang-Ping Yao. Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction[J]. The Journal of Biomedical Research, 2013, 27(5): 345-356. DOI: 10.7555/JBR.27.20130038
    [10]Sundeep?S.?Tumber, Hong?Liu. Epidural abscess after multiple lumbar punctures for labour epidural catheter placement[J]. The Journal of Biomedical Research, 2010, 24(4): 332-335. DOI: 10.1016/S1674-8301(10)60046-2

  • Cited by

    Periodical cited type(22)

    1. Ntalouka F, Tsirivakou A. Morus alba: natural and valuable effects in weight loss management. Front Clin Diabetes Healthc, 2024, 5: 1395688. DOI:10.3389/fcdhc.2024.1395688
    2. Kim KJ, Kim JY. Polyphenols in foods: a potential strategy for preventing and managing the postprandial hyperglycemic response. Food Sci Biotechnol, 2024, 33(12): 2699-2713. DOI:10.1007/s10068-024-01607-y
    3. Pal D, Mitra D, Hazra S, et al. Protective Effect of Aloe vera (L.) on Diabetes-Induced Oxidative Stress Linked Spermiological Co-Morbidity in Human and Rat: An In-Vitro Analysis. Reprod Sci, 2024, 31(9): 2685-2699. DOI:10.1007/s43032-024-01605-9
    4. Sip S, Sip A, Szulc P, et al. Exploring Beneficial Properties of Haskap Berry Leaf Compounds for Gut Health Enhancement. Antioxidants (Basel), 2024, 13(3): 357. DOI:10.3390/antiox13030357
    5. Chavan RS, Khatib NA, Hariprasad MG, et al. Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses. Heliyon, 2024, 10(2): e24907. DOI:10.1016/j.heliyon.2024.e24907
    6. Zhang P, Fan L, Zhang D, et al. In Vitro Anti-Tumor and Hypoglycemic Effects of Total Flavonoids from Willow Buds. Molecules, 2023, 28(22): 7557. DOI:10.3390/molecules28227557
    7. Bays HE, Bindlish S, Clayton TL. Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023. Obes Pillars, 2023, 5: 100056. DOI:10.1016/j.obpill.2023.100056
    8. Esposito F, Pala N, Carcelli M, et al. α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studies. J Enzyme Inhib Med Chem, 2023, 38(1): 2236802. DOI:10.1080/14756366.2023.2236802
    9. Sambashivaiah S, Cope M, Mukherjea R, et al. The Effect of Soy and Whey Protein Supplementation on Glucose Homeostasis in Healthy Normal Weight Asian Indians. J Nutr Metab, 2023, 2023: 2622057. DOI:10.1155/2023/2622057
    10. Qazi AI, Ahmad B, Sahibzada MUK, et al. Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats. Evid Based Complement Alternat Med, 2023, 2023: 1141554. DOI:10.1155/2023/1141554
    11. Chávez-Delgado EL, Jacobo-Velázquez DA. Essential Oils: Recent Advances on Their Dual Role as Food Preservatives and Nutraceuticals against the Metabolic Syndrome. Foods, 2023, 12(5): 1079. DOI:10.3390/foods12051079
    12. Carrillo-Arango HA, Atencio-Osorio MA, López-Álban CA, et al. Metabolic responses to acute sprint interval exercise training performed after an oral 75-gram glucose load in individuals with overweight/obesity. Physiol Rep, 2023, 11(2): e15555. DOI:10.14814/phy2.15555
    13. Teigen IA, Riaz M, Åm MK, et al. Vasodilatory effects of glucagon: A possible new approach to enhanced subcutaneous insulin absorption in artificial pancreas devices. Front Bioeng Biotechnol, 2022, 10: 986858. DOI:10.3389/fbioe.2022.986858
    14. Mitiku H, Kim TY, Kang H, et al. Selected coffee (Coffea arabica L.) extracts inhibit intestinal α-glucosidases activities in-vitro and postprandial hyperglycemia in SD Rats. BMC Complement Med Ther, 2022, 22(1): 249. DOI:10.1186/s12906-022-03726-7
    15. Mala P, Khan GA, Gopalan R, et al. Fijian medicinal plants and their role in the prevention of Type 2 diabetes mellitus. Biosci Rep, 2022, 42(11): BSR20220461. DOI:10.1042/BSR20220461
    16. Ahmed S, Ali MC, Ruma RA, et al. Molecular Docking and Dynamics Simulation of Natural Compounds from Betel Leaves (Piper betle L.) for Investigating the Potential Inhibition of Alpha-Amylase and Alpha-Glucosidase of Type 2 Diabetes. Molecules, 2022, 27(14): 4526. DOI:10.3390/molecules27144526
    17. Japar S, Fukunaga K, Kobayashi T, et al. A pilot study on the effect of D-allulose on postprandial glucose levels in patients with type 2 diabetes mellitus during Ramadan fasting. Diabetol Metab Syndr, 2022, 14(1): 86. DOI:10.1186/s13098-022-00856-3
    18. Ramzan F, Jayaprakash R, Pook C, et al. Acute Effects of Kawakawa (Piper excelsum) Intake on Postprandial Glycemic and Insulinaemic Response in a Healthy Population. Nutrients, 2022, 14(8): 1638. DOI:10.3390/nu14081638
    19. Fu'adah IT, Sumiwi SA, Wilar G. The Evolution of Pharmacological Activities Bouea macrophylla Griffith In Vivo and In Vitro Study: A Review. Pharmaceuticals (Basel), 2022, 15(2): 238. DOI:10.3390/ph15020238
    20. Srisongkram T, Waithong S, Thitimetharoch T, et al. Machine Learning and In Vitro Chemical Screening of Potential α-Amylase and α-Glucosidase Inhibitors from Thai Indigenous Plants. Nutrients, 2022, 14(2): 267. DOI:10.3390/nu14020267
    21. Tremblay-Franco M, Poupin N, Amiel A, et al. Postprandial NMR-Based Metabolic Exchanges Reflect Impaired Phenotypic Flexibility across Splanchnic Organs in the Obese Yucatan Mini-Pig. Nutrients, 2020, 12(8): 2442. DOI:10.3390/nu12082442
    22. Leri M, Scuto M, Ontario ML, et al. Healthy Effects of Plant Polyphenols: Molecular Mechanisms. Int J Mol Sci, 2020, 21(4): 1250. DOI:10.3390/ijms21041250

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article has an altmetric score of 1
    Article has an altmetric score of 1
    Article views (2707) PDF downloads (247) Cited by(22)
    Related

    ©2023 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return