Cover: Acute lung injury (ALI) associated with sepsis is characterized by a high mortality rate and limited treatment options. Recent research has shown that neutrophil extracellular traps (NETs) significantly contribute to the pathogenesis of ALI. Therefore, effective clearance of NETs presents a promising therapeutic strategy. Yan et al. (pages 569–584) found that medical ozone enhanced macrophage phagocytosis of NETs via the AMPK/SR-A1 signaling pathway, thereby improving outcomes of the ALI model mice. In the cover illustration, the large tree represents the lungs, while the withered yellow leaves and insect-infested branches on the left symbolizing inflamed and damaged lung tissues. In contrast, the green leaves on the right side of the tree represent healthy lung tissues, which flourish as a result of magpies clearing the insects. Here, magpies symbolize macrophages that play a crucial role in clearing NETs through phagocytosis, which may be enhanced by medical ozone. Cover art by Xuexian Zhu, Yan Wang, and Cheng Qian.

2024, 38(6): 569–584. DOI: 10.7555/JBR.38.20240038

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