Cover: Ferroptosis has emerged as a pivotal mode of programmed cell death. Since its discovery, ferroptosis has attracted considerable scientific interest, with numerous extensive studies highlighting its critical role in a broad spectrum of pathological processes. Zhang et al. (pages 413–435) provide a comprehensive overview of the regulatory frameworks, molecular mechanisms, and therapeutic implications related with ferroptosis. Its potential association with a range of pathological conditions, such as cancers, immunological diseases, neurodegenerative disorders, and other chronic diseases, is also summarized in this review. The cover illustration depicts a traditional Chinese intellectual game called Tangram. It is a dissection puzzle consisting of seven flat shapes. Many interesting patterns can be created by putting the seven shapes together intelligently. Analogously, ferroptosis is a pattern of iron-mediated regulatory cell death but highlights a critical role in a broad spectrum of pathological processes. Cover art by Xuexian Zhu and Cheng Qian.

2024, 38(5): 413–435. DOI: 10.7555/JBR.37.20230224

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