• ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 3
May  2021
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Article Contents
Wang Lei, Zhang Kun, Ding Xin, Wang Yan, Bai Hui, Yang Qing, Ben Jingjing, Zhang Hanwen, Li Xiaoyu, Chen Qi, Zhu Xudong. Fucoidan antagonizes diet-induced obesity and inflammation in mice[J]. The Journal of Biomedical Research, 2021, 35(3): 197-205. doi: 10.7555/JBR.34.20200153
Citation: Wang Lei, Zhang Kun, Ding Xin, Wang Yan, Bai Hui, Yang Qing, Ben Jingjing, Zhang Hanwen, Li Xiaoyu, Chen Qi, Zhu Xudong. Fucoidan antagonizes diet-induced obesity and inflammation in mice[J]. The Journal of Biomedical Research, 2021, 35(3): 197-205. doi: 10.7555/JBR.34.20200153

Fucoidan antagonizes diet-induced obesity and inflammation in mice

doi: 10.7555/JBR.34.20200153
More Information
  • Corresponding author: Qi Chen and Xudong Zhu, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Road, Nanjing, Jiangsu 211166, China. Tels: +86-25-86868843/+86-25-86869370, E-mails: qichen@njmu.edu.cn or zhuxudong@njmu.edu.cn; 
  • Received: 2020-09-14
  • Revised: 2020-11-05
  • Published: 2020-12-18
  • Issue Date: 2021-05-28
  • Obesity is an escalating global pandemic posing a serious threat to human health. The intervention therapy using weight-reducing drugs, accompanied by lifestyle modification, is a strategy for the treatment of obesity. In the present study, we explored the role of fucoidan, a seaweed compound, on high-fat diet (HFD)-induced obesity in mice. We found that fucoidan treatment significantly reduced the body fat and caused redistribution of visceral and subcutaneous fat in HFD-fed mice. Meanwhile, fucoidan treatment inhibited adipocyte hypertrophy and inflammation in adipose tissue. Collectively, these results suggest that fucoidan may be a promising treatment for obesity and obesity-induced complications.

     

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