Fucoidan antagonizes diet-induced obesity and inflammation in mice

Wang Lei; Zhang Kun; Ding Xin; Wang Yan; Bai Hui; Yang Qing; Ben Jingjing; Zhang Hanwen; Li Xiaoyu; Chen Qi; Zhu Xudong

doi:10.7555/JBR.34.20200153

Volume 35 Issue 3

May 2021

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The Journal of Biomedical Research > 2021 > 35(3): 197-205. > DOI: 10.7555/JBR.34.20200153

Wang Lei, Zhang Kun, Ding Xin, Wang Yan, Bai Hui, Yang Qing, Ben Jingjing, Zhang Hanwen, Li Xiaoyu, Chen Qi, Zhu Xudong. Fucoidan antagonizes diet-induced obesity and inflammation in mice[J]. The Journal of Biomedical Research, 2021, 35(3): 197-205. DOI: 10.7555/JBR.34.20200153

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Fucoidan antagonizes diet-induced obesity and inflammation in mice

Key Laboratory of Targeted Intervention of Cardiovascular Disease, CollaborativeInnovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China

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Corresponding author:
Qi Chen and Xudong Zhu, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, 101 Longmian Road, Nanjing, Jiangsu 211166, China. Tels: +86-25-86868843/+86-25-86869370, E-mails: qichen@njmu.edu.cn or zhuxudong@njmu.edu.cn
Received Date: September 13, 2020
Revised Date: November 04, 2020
Available Online: December 17, 2020

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Abstract

Abstract

Obesity is an escalating global pandemic posing a serious threat to human health. The intervention therapy using weight-reducing drugs, accompanied by lifestyle modification, is a strategy for the treatment of obesity. In the present study, we explored the role of fucoidan, a seaweed compound, on high-fat diet (HFD)-induced obesity in mice. We found that fucoidan treatment significantly reduced the body fat and caused redistribution of visceral and subcutaneous fat in HFD-fed mice. Meanwhile, fucoidan treatment inhibited adipocyte hypertrophy and inflammation in adipose tissue. Collectively, these results suggest that fucoidan may be a promising treatment for obesity and obesity-induced complications.
- obesity,
- adipose tissue,
- fucoidan,
- inflammation

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References (37)

References

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