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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 36 Issue 5
Sep.  2022
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Marta Obara-Michlewska. The contribution of astrocytes to obesity-associated metabolic disturbances[J]. The Journal of Biomedical Research, 2022, 36(5): 299-311. DOI: 10.7555/JBR.36.20200020
Citation: Marta Obara-Michlewska. The contribution of astrocytes to obesity-associated metabolic disturbances[J]. The Journal of Biomedical Research, 2022, 36(5): 299-311. DOI: 10.7555/JBR.36.20200020
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The contribution of astrocytes to obesity-associated metabolic disturbances

  • Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw 02-106, Poland

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  • Corresponding author:

    Marta Obara-Michlewska, Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 A. Pawinskiego Street, Warsaw 02-106, Poland. Tel/Fax: +48-22-6046416, E-mail: mobara@imdik.pan.pl

  • Received Date: January 25, 2022
  • Revised Date: June 20, 2022
  • Accepted Date: July 10, 2022
  • Available Online: August 27, 2022
    Graphical Abstract
    • Abstract
  • Obesity is a worldwide health, economic and social concern, despite efforts made to counteract the spreading wave of eating and nourishment-associated disorders. The review aims to show how the glial cells, astrocytes, contribute to the central regulation of appetite and energy metabolism. The hypothalamus is the brain center responsible for nutrients and nutritional hormone sensing, signal processing, and execution of metabolic and behavioral responses, directed at sustaining energy homeostasis. The astrocytes are endowed with receptors, transporters and enzymatic machinery responsible for glucose, lactate, fatty acids, ketone bodies, as well as leptin or ghrelin transport and metabolism, and that render them supporters and partners for neurons in governing the brain and body energy intake and expenditure. However, the role of astrocytes associated with brain energy metabolism reaches far beyond simple fuel contingent—they contribute to cognitive performance. The cognitive decline which often accompanies high fat- and/or high-calorie diets and correlates with neuroinflammation and astrogliosis, is a major concern. The last two decades of research enabled us to acknowledge the astroglia in obesity-associated dysfunctions and to investigate astrocytes as contributors to the pathology, as well as targets for therapy.
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  • CLC number: R589, Document code: A

    The authors reported no conflict of interests.

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