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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 3
Apr.  2016
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Chun Yuan, Xiaoqiang Liu, Yundong Mao, Feiyang Diao, Yugui Cui, Jiayin Liu. Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study[J]. The Journal of Biomedical Research, 2016, 30(3): 197-202. DOI: 10.7555/JBR.30.20140111
Citation: Chun Yuan, Xiaoqiang Liu, Yundong Mao, Feiyang Diao, Yugui Cui, Jiayin Liu. Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study[J]. The Journal of Biomedical Research, 2016, 30(3): 197-202. DOI: 10.7555/JBR.30.20140111
shu

Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study

  • The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210036, China

Funds: 

The Major State Basic Research Development Program of China (973 Program: No. 2012CB944902 and No. 2012CB944703), the National Natural Science Foundation of China (No. 30801236), and the PriorityAcademic Program Development of Jiangsu HigherEducation Institutions

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  • Received Date: June 22, 2014
  • Revised Date: September 02, 2014
    Graphical Abstract
    • Abstract
  • Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China. We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index (BMI), total testosterone (TT), modified Ferriman–Gallwey hirsutism score, sex hormone binding globulin (SHBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index (FAI) between PCOS patients and controls and subgroups of PCOS. The prevalence of acne and hirsutism did not differ significantly between the hyperandrogenic and non-hyperandrogenic subgroup. Patients with signs of hyperandrogenism had significantly higher BMI (P < 0.05), but differences in TT, SHBG, FAI and waist/hip ratio were insignificant. The odds ratio of overweight was calculated for all PCOS patients. Our results suggest that PCOS patients with high BMI tend to have functional disorders of androgen excess; therefore, BMI may be a strong predictor of hyperandrogenism in PCOS.
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