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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 33 Issue 5
Sep.  2019
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Jia Meiqun, Ren Lulu, Hu Lingmin, Ma Hongxia, Jin Guangfu, Li Dake, Li Ni, Hu Zhibin, Hang Dong. Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women[J]. The Journal of Biomedical Research, 2019, 33(5): 308-316. DOI: 10.7555/JBR.33.20180096
Citation: Jia Meiqun, Ren Lulu, Hu Lingmin, Ma Hongxia, Jin Guangfu, Li Dake, Li Ni, Hu Zhibin, Hang Dong. Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women[J]. The Journal of Biomedical Research, 2019, 33(5): 308-316. DOI: 10.7555/JBR.33.20180096
shu

Association of long non-coding RNA HOTAIR and MALAT1 variants with cervical cancer risk in Han Chinese women

  • 1.

    Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 2.

    Department of Gynecologic Oncology, the Affiliated Tumor Hospital of Nantong University (Nantong Tumor Hospital), Nantong, Jiangsu 226361, China

  • 3.

    Department of Reproduction, the Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, China

  • 4.

    Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing 211166, China

  • 5.

    Department of Gynecologic Oncology, Nanjing Maternity and Child Health Hospital, Nanjing, Jiangsu 210004, China

  • 6.

    Program Office for Cancer Screening in Urban China, National Cancer Centre/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

  • 7.

    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China

More Information
  • Corresponding author:

    Dong Hang and Zhibin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, No. 101 Longmian Ave, Nanjing, Jiangsu 211166, China. Tel/Fax: +86-25-8686-8438/+86-25-8686-8437, E-mails: hangdong@njmu.edu.cn and zhibin_hu@njmu.edu.cn

    hangdong@njmu.edu.cn

  • Received Date: September 30, 2018
  • Revised Date: December 02, 2019
  • Accepted Date: February 25, 2019
  • Available Online: April 29, 2019
    Graphical Abstract
    • Abstract
  • Long noncoding RNA (lncRNA) HOTAIR and MALAT1 are implicated in the development of multiple cancers. Genetic variants within HOTAIR and MALAT1 may affect the gene expression, thereby modifying genetic susceptibility to cervical cancer. A case-control study was designed, including 1 486 cervical cancer patients and 1 536 healthy controls. Based on RegulomeDB database, 11 SNPs were selected and genotyped by using Sequenom's Mass ARRAY. Univariate and multivariate logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (CI). We found that the A allele of rs35643724 in HOTAIR was associated with increased risk of cervical cancer, while the C allele of rs1787666 in MALAT1 was associated with decreased risk. Compared to individuals with 0–1 unfavorable allele, those with 3–4 unfavorable alleles showed 18% increased odds of having cervical cancer. Our findings suggest that HOTAIR rs35643724 and MALAT1 rs1787666 might represent potential biomarkers for cervical cancer susceptibility.
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    • References (38)
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