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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 2
Mar.  2021
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Song Jun, Zhang Jifeng, Xu Jie, Garcia-Barrio Minerva, Chen Y. Eugene, Yang Dongshan. Genome engineering technologies in rabbits[J]. The Journal of Biomedical Research, 2021, 35(2): 135-147. DOI: 10.7555/JBR.34.20190133
Citation: Song Jun, Zhang Jifeng, Xu Jie, Garcia-Barrio Minerva, Chen Y. Eugene, Yang Dongshan. Genome engineering technologies in rabbits[J]. The Journal of Biomedical Research, 2021, 35(2): 135-147. DOI: 10.7555/JBR.34.20190133
shu

Genome engineering technologies in rabbits

  • Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA

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  • Corresponding author:

    Y. Eugene Chen and Dongshan Yang, Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Tel/Fax: +1-734-647-5742/+1-734-763-7097, E-mails: echenum@umich.edu and doyang@umich.edu

  • Received Date: October 21, 2019
  • Accepted Date: April 28, 2020
  • Available Online: June 11, 2020
    Graphical Abstract
    • Abstract
  • The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for generating rabbit models of human genetic diseases. In this review, we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.
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    • References (134)
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