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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 33 Issue 4
Jun.  2019
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Niimi Manabu, Nishijima Kazutoshi, Kitajima Shuji, Matsuhisa Fumikazu, Satoh Kaneo, Yamazaki Hirokazu, Zhang Jifeng, Chen Y. Eugene, Fan Jianglin. Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits[J]. The Journal of Biomedical Research, 2019, 33(4): 271-279. DOI: 10.7555/JBR.33.20180097
Citation: Niimi Manabu, Nishijima Kazutoshi, Kitajima Shuji, Matsuhisa Fumikazu, Satoh Kaneo, Yamazaki Hirokazu, Zhang Jifeng, Chen Y. Eugene, Fan Jianglin. Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits[J]. The Journal of Biomedical Research, 2019, 33(4): 271-279. DOI: 10.7555/JBR.33.20180097
shu

Macrophage-derived matrix metalloproteinase-1 enhances aortic aneurysm formation in transgenic rabbits

  • 1.

    Department of Molecular Pathology, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan

  • 2.

    Animal Research Laboratory, Bioscience Education-Research Support Center, Akita University, Akita 010-8502, Japan

  • 3.

    Analytical Research Center for Experimental Sciences, Saga University, Saga 840-8502, Japan

  • 4.

    Department of Laboratory Medicine, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan

  • 5.

    Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA

  • 6.

    School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China

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  • Corresponding author:

    Jianglin Fan, Department of Molecular Pathology, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, China. E-mail: jianglin@yamanashi.ac.jp

  • Received Date: September 30, 2018
  • Accepted Date: November 27, 2018
  • Available Online: February 27, 2019
    Graphical Abstract
    • Abstract
  • Increased expression of matrix metalloproteinase-1 (MMP-1) has been observed in the lesions of atherosclerosis and aneurysms; however, it is not fully understood whether macrophage-derived MMP-1 affects these diseases. To investigate whether macrophage-derived MMP-1 participates in the development of vascular diseases, we generated transgenic (Tg) rabbits expressing human MMP-1 in the monocyte/macrophage lineage under the control of the human scavenger receptor enhancer/promoter. Tg rabbits exhibited no visible abnormalities throughout their bodies. Western blotting analysis revealed that the amount of MMP-1 proteins in the conditioned media secreted from peritoneal macrophages of Tg rabbits was up to 3-fold higher than that in non-Tg rabbits. For the first experiment, Tg and non-Tg rabbits were fed a cholesterol diet for 16 weeks, and aortic and coronary atherosclerosis were evaluated. The gross lesion area of aortic atherosclerosis in Tg rabbits was not significantly different from that in non-Tg rabbits, but Tg rabbits had marked destruction of the medial elastic lamina of the aortic lesions on microscopic examination. For the second experiment, we generated aortic aneurysms by incubating with elastase. Compared with non-Tg rabbits, Tg rabbits exhibited a significantly greater aortic dilation. Increased macrophage-derived MMP-1 led to increased medial destruction in both aortic atherosclerosis and aneurysms. These results demonstrate that MMP-1 plays a different role in the pathogenesis of atherosclerosis and aneurysms.
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    • References (33)
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