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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 3
Apr.  2016
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Nisha Gupta, Dan G. Duda. Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer[J]. The Journal of Biomedical Research, 2016, 30(3): 181-185. DOI: 10.7555/JBR.30.20150114
Citation: Nisha Gupta, Dan G. Duda. Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer[J]. The Journal of Biomedical Research, 2016, 30(3): 181-185. DOI: 10.7555/JBR.30.20150114
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Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer

  • Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital Research Institute, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA.

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NIH grants R01- CA159258 and P01-CA080124 and by American Cancer Society Grant 120733-RSG-11-073-01-TBG

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  • Received Date: August 07, 2015
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    • Abstract
  • Metastatic prostate cancer is one of the leading causes of cancer-related death in men. The primary site of metastasis from prostate cancers is the bone. During the last decade, multiple studies have pointed to the role of the stromal cell-derived factor 1 alpha (SDF1α)/CXCR4 axis in the metastatic spread of the disease, but the mechanisms that underlie this effect are still incompletely understood. In this review, we summarize the current understanding of the role of the SDF1α/CXCR4 pathway in bone metastatic prostate cancer. We also discuss the therapeutic potential of disrupting the interaction between prostate tumor cells and bone environment with focus on the SDF1α pathway.
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    2. Yuan M, Zhu Z, Mao W, et al. Anlotinib Combined With Anti-PD-1 Antibodies Therapy in Patients With Advanced Refractory Solid Tumors: A Single-Center, Observational, Prospective Study. Front Oncol, 2021, 11: 683502. DOI:10.3389/fonc.2021.683502
    3. Karolczak K, Watala C. Blood Platelets as an Important but Underrated Circulating Source of TGFβ. Int J Mol Sci, 2021, 22(9): 4492. DOI:10.3390/ijms22094492
    4. Adekoya TO, Richardson RM. Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis. Int J Mol Sci, 2020, 21(12): 4449. DOI:10.3390/ijms21124449
    5. Zhang X. Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer. Cancer Commun (Lond), 2019, 39(1): 76. DOI:10.1186/s40880-019-0425-1
    6. Hudson LG, Gillette JM, Kang H, et al. Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase. Cancers (Basel), 2018, 10(10): 358. DOI:10.3390/cancers10100358
    7. Zambon JP, Patel M, Hemal A, et al. Nonhuman primate model of persistent erectile and urinary dysfunction following radical prostatectomy: Feasibility of minimally invasive therapy. Neurourol Urodyn, 2018, 37(7): 2141-2150. DOI:10.1002/nau.23536
    8. Kim GS, Heo JR, Kim SU, et al. Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-β Against Choriocarcinoma in Xenografted Metastatic Mouse Models. Transl Oncol, 2018, 11(1): 74-85. DOI:10.1016/j.tranon.2017.11.003
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