• ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 4
Jul.  2016
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Article Contents
Xinli Liu. Bone site-specific delivery of siRNA[J]. The Journal of Biomedical Research, 2016, 30(4): 264-271. doi: 10.7555/JBR.30.20150110
Citation: Xinli Liu. Bone site-specific delivery of siRNA[J]. The Journal of Biomedical Research, 2016, 30(4): 264-271. doi: 10.7555/JBR.30.20150110

Bone site-specific delivery of siRNA

doi: 10.7555/JBR.30.20150110
Funds:

the Cancer Prevention Research Institute of Texas (CPRIT, RP150656, X.L.) and National Institute of Health (NIH/NCI, R15CA182769,X.L.)

  • Received: 2015-08-05
  • Revised: 2015-08-25
  • Issue Date: 2016-07-28
  • Small interfering RNAs (siRNA) have enormous potential as therapeutics to target and treat various bone disor-ders such as osteoporosis and cancer bone metastases. However, effective and specifc delivery of siRNA therapeu-tics to bone and bone-specifc cells in vivo is very challenging. To realize the full therapeutic potential of siRNA intreating bone disorders, a safe and effcient, tissue- and cell-specifc delivery system must be developed. This review focuses on recent advances in bone site-specifc delivery of siRNA at the tissue or cellular level. Bone-targeted nanoparticulate siRNA carriers and various bone-targeted moieties such as bisphosphonates, oligopeptides (Asp)8and (AspSerSer)6, and aptamers are highlighted. Incorporation of these bone-seeking targeting moieties into siRNA carriers allows for recognition of different sub-tissue functional domains of bone and also specifc cell types residing in bone tissue. It also provides a means for bone-formation surface-, bone-resorption surface-, or osteoblast- specifc targeting and transportation of siRNA therapeutics. The discussion mainly focuses on systemic and local bone-specifc delivery of siRNA in osteoporosis and bone metastasis preclinical models.

     

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