4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Qi Zheng, Kejun Nan, Yu Yao. Gastric cancer presenting with solitary gigantic pelvic metastasis[J]. The Journal of Biomedical Research, 2012, 26(4): 303-306. DOI: 10.7555/JBR.26.20110056
Citation: Qi Zheng, Kejun Nan, Yu Yao. Gastric cancer presenting with solitary gigantic pelvic metastasis[J]. The Journal of Biomedical Research, 2012, 26(4): 303-306. DOI: 10.7555/JBR.26.20110056

Gastric cancer presenting with solitary gigantic pelvic metastasis

More Information
  • Received Date: May 16, 2011
  • Bone metastasis of gastric cancer is relatively uncommon in clinical practice. Moreover, it is all the more unu-sual for the primary presentation of gastric malignancy to be bone metastasis. Here, we describe a male patient who complained of pain and edema in his right lower extremity. Further assessment by computed tomography and positron emission tomography revealed an abnormally thickened gastric cardia and a giant neoplasm in the right pelvis with bone damage. Consequently, the finding of adenocarcinoma cells in pelvic and cardia biopsy speci-mens contributed to the diagnosis of pelvic metastasis from gastric cancer. This case report illustrates that stomach cancer has the potential, although far less than breast, prostate and lung cancers, to metastasize to bone. In addi-tion, it highlights the peculiarity of this bone metastasis which is pelvic, solitary and huge.
  • Related Articles

    [1]Fangyuan Li, Yaohui Wang, Xiaochun Ping, Jiani C. Yin, Fufeng Wang, Xian Zhang, Xiang Li, Jing Zhai, Lizong Shen. Molecular evolution of intestinal-type early gastric cancer according to Correa cascade[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240118
    [2]Zhang Weifeng, Chen Han, Zhang Guoxin, Jin Guangfu. A nomogram for predicting lymph node metastasis in superficial esophageal squamous cell carcinoma[J]. The Journal of Biomedical Research, 2021, 35(5): 361-370. DOI: 10.7555/JBR.35.20210034
    [3]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [4]Haibo Tong, Chunlin Zou, Siyuan Qin, Jie Meng, Evan T. Keller, Jian Zhang, Yi Lu. Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-kB signaling[J]. The Journal of Biomedical Research, 2018, 32(5): 343-353. DOI: 10.7555/JBR.32.20180035
    [5]Xinli Liu. Bone site-specific delivery of siRNA[J]. The Journal of Biomedical Research, 2016, 30(4): 264-271. DOI: 10.7555/JBR.30.20150110
    [6]Nisha Gupta, Dan G. Duda. Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer[J]. The Journal of Biomedical Research, 2016, 30(3): 181-185. DOI: 10.7555/JBR.30.20150114
    [7]Yang Zhou, Ouyang Ling, Li Bo. Expression and significance of lysyl oxidase-like 1 and fibulin-5 in the cardinal ligament tissue of patients with pelvic floor dysfunction[J]. The Journal of Biomedical Research, 2013, 27(1): 23-28. DOI: 10.7555/JBR.27.20110142
    [8]Di Liu, Peng Xia, Dongmei Diao, Yao Cheng, Hao Zhang, Dawei Yuan, Chen Huang, Chengxue Dang. MiRNA-429 suppresses the growth of gastric cancer cells in vitro[J]. The Journal of Biomedical Research, 2012, 26(5): 389-393. DOI: 10.7555/JBR.26.20120029
    [9]Yao Liu, Qin Zhang, Chuanli Ren, Yanbing Ding, Guangfu Jin, Zhibin Hu, Yaochu Xu, Hongbing Shen. A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population[J]. The Journal of Biomedical Research, 2012, 26(5): 315-318. DOI: 10.7555/JBR.26.20110087
    [10]Li Liu, Qi Chen, Rensheng Lai, Xiaobin Wu, Xiaoyu Wu, Fukun Liu, Guohua Xu, Yong Ji. Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer[J]. The Journal of Biomedical Research, 2010, 24(3): 187-197.
  • Cited by

    Periodical cited type(23)

    1. Jia Z, Zhang X, Li Z, et al. Hydrogen sulfide mitigates ox‑LDL‑induced NLRP3/caspase‑1/GSDMD dependent macrophage pyroptosis by S‑sulfhydrating caspase‑1. Mol Med Rep, 2024, 30(2): 135. DOI:10.3892/mmr.2024.13259
    2. Flori L, Benedetti G, Calderone V, et al. Hydrogen Sulfide and Irisin, Potential Allies in Ensuring Cardiovascular Health. Antioxidants (Basel), 2024, 13(5): 543. DOI:10.3390/antiox13050543
    3. Gonzalez AL, Dungan MM, Smart CD, et al. Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease. Antioxid Redox Signal, 2024, 40(4-6): 292-316. DOI:10.1089/ars.2023.0284
    4. Andrés CMC, Pérez de la Lastra JM, Andrés Juan C, et al. Chemistry of Hydrogen Sulfide-Pathological and Physiological Functions in Mammalian Cells. Cells, 2023, 12(23): 2684. DOI:10.3390/cells12232684
    5. Bechelli C, Macabrey D, Deglise S, et al. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease. Int J Mol Sci, 2023, 24(12): 9955. DOI:10.3390/ijms24129955
    6. Munteanu C. Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives. Int J Mol Sci, 2023, 24(9): 8376. DOI:10.3390/ijms24098376
    7. Star BS, van der Slikke EC, Ransy C, et al. GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide: Quinone Oxidoreductase in Endothelial Cells. Antioxidants (Basel), 2023, 12(3): 587. DOI:10.3390/antiox12030587
    8. Zhang X, Wang Z, Zheng Y, et al. Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review). Int J Mol Med, 2023, 51(4): 35. DOI:10.3892/ijmm.2023.5238
    9. Liu J, Mesfin FM, Hunter CE, et al. Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter. Antioxidants (Basel), 2022, 11(9): 1788. DOI:10.3390/antiox11091788
    10. Zhu C, Liu Q, Li X, et al. Hydrogen sulfide: A new therapeutic target in vascular diseases. Front Endocrinol (Lausanne), 2022, 13: 934231. DOI:10.3389/fendo.2022.934231
    11. Munteanu C, Rotariu M, Turnea M, et al. Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)-A Systematic Review. Int J Mol Sci, 2022, 23(12): 6720. DOI:10.3390/ijms23126720
    12. Zhao H, Liu H, Yang Y, et al. The Role of H2S Regulating NLRP3 Inflammasome in Diabetes. Int J Mol Sci, 2022, 23(9): 4818. DOI:10.3390/ijms23094818
    13. Guo Z, Du X, Zhang Y, et al. Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis. Front Cardiovasc Med, 2022, 8: 785554. DOI:10.3389/fcvm.2021.785554
    14. Doran AC. Inflammation Resolution: Implications for Atherosclerosis. Circ Res, 2022, 130(1): 130-148. DOI:10.1161/CIRCRESAHA.121.319822
    15. Wu W, Tan QY, Xi FF, et al. NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency. Exp Ther Med, 2022, 23(1): 94. DOI:10.3892/etm.2021.11017
    16. Zhou M, Chen JY, Chao ML, et al. S-nitrosylation of c-Jun N-terminal kinase mediates pressure overload-induced cardiac dysfunction and fibrosis. Acta Pharmacol Sin, 2022, 43(3): 602-612. DOI:10.1038/s41401-021-00674-9
    17. Rose P, Zhu YZ, Moore PK. Hydrogen Sulfide and the Immune System. Adv Exp Med Biol, 2021, 1315: 99-128. DOI:10.1007/978-981-16-0991-6_5
    18. Wang YZ, Ngowi EE, Wang D, et al. The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases. Int J Mol Sci, 2021, 22(4): 2194. DOI:10.3390/ijms22042194
    19. Gáll T, Pethő D, Nagy A, et al. Therapeutic Potential of Carbon Monoxide (CO) and Hydrogen Sulfide (H2S) in Hemolytic and Hemorrhagic Vascular Disorders-Interaction between the Heme Oxygenase and H2S-Producing Systems. Int J Mol Sci, 2020, 22(1): 47. DOI:10.3390/ijms22010047
    20. Mohammad G, Radhakrishnan R, Kowluru RA. Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy. Invest Ophthalmol Vis Sci, 2020, 61(14): 35. DOI:10.1167/iovs.61.14.35
    21. Rahman MA, Glasgow JN, Nadeem S, et al. The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis. Front Cell Infect Microbiol, 2020, 10: 586923. DOI:10.3389/fcimb.2020.586923
    22. Wang H, Shi X, Qiu M, et al. Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome. Int J Biol Sci, 2020, 16(14): 2752-2760. DOI:10.7150/ijbs.47595
    23. Tian Y, Song H, Qin W, et al. Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission. Front Physiol, 2020, 11: 897. DOI:10.3389/fphys.2020.00897

    Other cited types(0)

Catalog

    Article Metrics

    Article views (3995) PDF downloads (91) Cited by(23)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return