• ISSN 1674-8301
  • CN 32-1810/R
Volume 27 Issue 4
Jul.  2013
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Article Contents
Tinghua Hu, Yu Yao, Shuo Yu, Hui Guo, Lili Han, Wenjuan Wang, Tao Tian, Yibin Hao, Zhiyan Liu, Kejun Nan, Shuhong Wang. Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer[J]. The Journal of Biomedical Research, 2013, 27(4): 283-290. doi: 10.7555/JBR.27.20130069
Citation: Tinghua Hu, Yu Yao, Shuo Yu, Hui Guo, Lili Han, Wenjuan Wang, Tao Tian, Yibin Hao, Zhiyan Liu, Kejun Nan, Shuhong Wang. Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer[J]. The Journal of Biomedical Research, 2013, 27(4): 283-290. doi: 10.7555/JBR.27.20130069

Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer

doi: 10.7555/JBR.27.20130069
Funds:

This study was supported by the National Natural Science Foundation of China (No. 81172361, 81001090 and 81201824)

Specialized Research Fund for the Doctoral Program of Higher Education of China, the First Affiliated Hospital of Medical School of Xi'an Jiaotong University, the Fundamental Research of Xi'an Jiaotong University (No.20110201120061)

Fundamental Research Funds for the Central Universities (No.xjj2010013)

  • Received: 2013-05-04
  • Issue Date: 2013-07-28
  • The CXCR4 and Nrf2 signaling pathways are abnormally activated in response to cellular stress in various types of human cancers. In this study, we examined the expression of CXCR4 and Nrf2 in colorectal cancer (CRC) tissue specimens and investigated their correlation with patient clinicopathologic characteristics. We determined CXCR4 and Nrf2 expression in 76 CRC tissue specimens and paired normal tissue specimens by immunohisto-chemistry and real-time PCR. We found that the protein and mRNA transcript levels of CXCR4 were significantly higher in CRC tissue specimens than in paired normal tissues, while the expressions of Nrf2 protein and mRNA were increased in CRC tissues compared to distant non-cancerous tissues. High expression level of CXCR4 was positively correlated with poorly differentiated (P = 0.031), more advanced tumor-node-metastasis (TNM) stage (P = 0.019), lymph node metastasis (P = 0.007) and distant metastasis (P = 0.018). However, the expression of Nrf2 protein was positively correlated with larger tumor size (P = 0.049), more advanced TNM stage (P = 0.013), lymph node metastasis (P = 0.016) and distant metastasis (P = 0.023). Moreover, there was a strong relation-ship between CXCR4 and Nrf2 expression in CRC tissues, indicating that high Nrf2 expression may contribute to CXCR4 overexpression. In addition, combined expression of CXCR4 and Nrf2 strongly correlated with lymph node metastasis and distant metastasis (P = 0.003). Furthermore, we found that combined high expression of CXCR4 and Nrf2 had stronger correlation with lymph node metastasis and distant metastasis than any single molecule did. This study indicated that the abnormal expression of CXCR4 and Nrf2 contributed to the progression of CRC.

     

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