4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Min Lu, Qun Lu, Yong Zhang, Gang Tian. ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity[J]. The Journal of Biomedical Research, 2011, 25(4): 266-273. DOI: 10.1016/S1674-8301(11)60036-5
Citation: Min Lu, Qun Lu, Yong Zhang, Gang Tian. ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity[J]. The Journal of Biomedical Research, 2011, 25(4): 266-273. DOI: 10.1016/S1674-8301(11)60036-5

ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity

Funds: 

This study was supported by National High-Tech Research and De-velopment Program of China (No.2006AA02A406) and Natural Sci-ence Foundation of China (No.30871042)

More Information
  • We investigated the relationship of apoB/apoA1 ratio and coronary heart disease (CHD) in persons who were overweight or obese. The subjects were divided by the body mass indexes (BMI) into the normal weight group (n=397, BMI<24 kg/m2) and the overweight group (n=400, BMI>24 kg/m2). Our results showed that the over-weight group had higher blood pressure [(130.15±19.01) mmHg vs (123.66±18.70) mmHg] and higher levels of blood sugar [(7.09±2.89) mmol/L vs (6.21±2.59) mmol/L], triglyceride [(1.93±1.19) mmol/L vs (1.44±0.85) mmol/L], total cholesterol [(4.26±1.06) mmol/L vs (4.09±0.99) mmol/L], low-density lipoprotein cholesterol (LDL-C) [(2.56±0.75) mmol/L vs (2.39±0.72) mmol/L], and apoB [(0.83±0.27) mg/L vs (0.78±0.23) mg/L], and a higher apoB/apoA1 ratio (0.83±0.27 vs 0.75±0.25) and lower levels high-density lipoprotein cholesterol [(1.10±0.26) mmol/L vs (1.21±0.31) mmol/L] and apoA1 [(1.04±0.20) mg/L vs (1.08±0.22) mg/L] than those of the normal weight group (all P < 0.05). The prevalence of CHD in the over-weight group in the lowest LDL quar-tile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the low-est apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve (AUC) was the highest for apoB/apoA1 (0.655). The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
  • Related Articles

    [1]Izzatullo Ziyoyiddin o`g`li Abdullaev, Ulugbek Gapparjanovich Gayibov, Sirojiddin Zoirovich Omonturdiev, Sobirova Fotima Azamjonovna, Sabina Narimanovna Gayibova, Takhir Fatikhovich Aripov. Molecular pathways in cardiovascular disease under hypoxia: Mechanisms, biomarkers, and therapeutic targets[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240387
    [2]Xue Zhang, Dan Zhang, Lei Huo, Xin Zhou, Jia Zhang, Min Li, Dongming Su, Peng Sun, Fang Chen, Xiubin Liang. Upregulation of α-ENaC induces pancreatic β-cell dysfunction, ER stress, and SIRT2 degradation[J]. The Journal of Biomedical Research, 2024, 38(3): 241-255. DOI: 10.7555/JBR.37.20230128
    [3]Pengxi Shi, Ao Tan, Yuanyuan Ma, Lingli Que, Chuanfu Li, Yongfeng Shao, Haoliang Sun, Yuehua Li, Jiantao Li. MicroRNA-19a-3p augments TGF-β1-induced cardiac fibroblast activation via targeting BAMBI[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.37.20230313
    [4]Cui Qi, Jiaqi Zhang, Yuanyuan Wang, Mingyan Lin, Jun Gao, Haiying Lu. Valproic acid enhances neurosphere formation in cultured rat embryonic cortical cells through TGFβ1 signaling[J]. The Journal of Biomedical Research, 2022, 36(2): 127-140. DOI: 10.7555/JBR.36.20210109
    [5]Nolan B. Ayers, Chenming Sun, Shi-You Chen. Transforming growth factor-β signaling in systemic sclerosis[J]. The Journal of Biomedical Research, 2018, 32(1): 3-12. DOI: 10.7555/JBR.31.20170034
    [6]Ankit Mahajan, Swarkar Sharma, Manoj K. Dhar, Rameshwar N.K. Bamezai. Risk factors of type 2 diabetes in population of Jammu and Kashmir, India[J]. The Journal of Biomedical Research, 2013, 27(5): 372-379. DOI: 10.7555/JBR.27.20130043
    [7]Guanhua Su, Kun Liu, Yan Wang, Jue Wang, Xiaowei Li, Wenzhu Li, Yuhua Liao, Zhaohui Wang. Fibrinogen-like protein 2 expression correlates with microthrombosis in rats with type 2 diabetic nephropathy[J]. The Journal of Biomedical Research, 2011, 25(2): 120-127. DOI: 10.1016/S1674-8301(11)60015-8
    [8]Juan Du, Hui Shi, Ying Lu, Wencong Du, Yuanyuan Cao, Qian Li, Jianhua Ma, Xinhua Ye, Jinluo Cheng, Xiaofang Yu, Yanqin Gao, Ling Zhou. Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population[J]. The Journal of Biomedical Research, 2011, 25(1): 33-41. DOI: 10.1016/S1674-8301(11)60004-3
    [9]Haiyang?Qian, Zhifang?Song, Meilin?Wang, Xiaomin?Jia, Aiping?Li, Ye?Yang, Lianlian?Shen, Shasha?Wang, Chunhui?Ni, Jianwei?Zhou. Association of transforming growth factor-β1 gene variants with risk of coal workers pneumoconiosis[J]. The Journal of Biomedical Research, 2010, 24(4): 270-276. DOI: 10.1016/S1674-8301(10)60038-3
    [10]Wei Qin, Xin Chen, Peisheng Liu. Inhibition of TGF-β1 by eNOS gene transfer provides cardiac protection after myocardial infarction[J]. The Journal of Biomedical Research, 2010, 24(2): 145-152.

Catalog

    Article Metrics

    Article views (6625) PDF downloads (3171) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return