4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Min Lu, Qun Lu, Yong Zhang, Gang Tian. ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity[J]. The Journal of Biomedical Research, 2011, 25(4): 266-273. DOI: 10.1016/S1674-8301(11)60036-5
Citation: Min Lu, Qun Lu, Yong Zhang, Gang Tian. ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity[J]. The Journal of Biomedical Research, 2011, 25(4): 266-273. DOI: 10.1016/S1674-8301(11)60036-5

ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity

Funds: 

This study was supported by National High-Tech Research and De-velopment Program of China (No.2006AA02A406) and Natural Sci-ence Foundation of China (No.30871042)

More Information
  • We investigated the relationship of apoB/apoA1 ratio and coronary heart disease (CHD) in persons who were overweight or obese. The subjects were divided by the body mass indexes (BMI) into the normal weight group (n=397, BMI<24 kg/m2) and the overweight group (n=400, BMI>24 kg/m2). Our results showed that the over-weight group had higher blood pressure [(130.15±19.01) mmHg vs (123.66±18.70) mmHg] and higher levels of blood sugar [(7.09±2.89) mmol/L vs (6.21±2.59) mmol/L], triglyceride [(1.93±1.19) mmol/L vs (1.44±0.85) mmol/L], total cholesterol [(4.26±1.06) mmol/L vs (4.09±0.99) mmol/L], low-density lipoprotein cholesterol (LDL-C) [(2.56±0.75) mmol/L vs (2.39±0.72) mmol/L], and apoB [(0.83±0.27) mg/L vs (0.78±0.23) mg/L], and a higher apoB/apoA1 ratio (0.83±0.27 vs 0.75±0.25) and lower levels high-density lipoprotein cholesterol [(1.10±0.26) mmol/L vs (1.21±0.31) mmol/L] and apoA1 [(1.04±0.20) mg/L vs (1.08±0.22) mg/L] than those of the normal weight group (all P < 0.05). The prevalence of CHD in the over-weight group in the lowest LDL quar-tile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the low-est apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve (AUC) was the highest for apoB/apoA1 (0.655). The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
  • Related Articles

    [1]Jubiao Zhang, Yang Chen, Lihong Yan, Xin Zhang, Xiaoyan Zheng, Junxia Qi, Fen Yang, Juxue Li. EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice[J]. The Journal of Biomedical Research, 2023, 37(3): 179-193. DOI: 10.7555/JBR.36.20220168
    [2]Marta Obara-Michlewska. The contribution of astrocytes to obesity-associated metabolic disturbances[J]. The Journal of Biomedical Research, 2022, 36(5): 299-311. DOI: 10.7555/JBR.36.20200020
    [3]Wang Lei, Zhang Kun, Ding Xin, Wang Yan, Bai Hui, Yang Qing, Ben Jingjing, Zhang Hanwen, Li Xiaoyu, Chen Qi, Zhu Xudong. Fucoidan antagonizes diet-induced obesity and inflammation in mice[J]. The Journal of Biomedical Research, 2021, 35(3): 197-205. DOI: 10.7555/JBR.34.20200153
    [4]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [5]Kyriakos E. Kypreos, Eleni A. Karavia, Caterina Constantinou, Aikaterini Hatziri, Christina Kalogeropoulou, Eva Xepapadaki, Evangelia Zvintzou. Apolipoprotein E in diet-induced obesity: a paradigm shift from conventional perception[J]. The Journal of Biomedical Research, 2018, 32(3): 183-190. DOI: 10.7555/JBR.32.20180007
    [6]Xiaoyang Liu, Chunlin Zheng, Cheng Xu, Qian Liu, Jin Wang, Yongzhi Hong, Peng Zhao. Nighttime snacking is associated with risk of obesity and hyperglycemia in adults: a cross-sectional survey from Chinese adult teachers[J]. The Journal of Biomedical Research, 2017, 31(6): 541-547. DOI: 10.7555/JBR.31.20160083
    [7]Celia Aradillas-García, Miguel Cruz, Elva Pérez-Luque, María E. Garay-Sevilla, Juan M. Malacara, Aduna R, Jesús Peralta, Ana Burguete-García, Jorge A. Alegría-Torres. Obesity is associated with the Arg389Gly ADRB1 but not with the Trp64Arg ADRB3 polymorphism in children from San Luis Potosí and León, México[J]. The Journal of Biomedical Research, 2017, 31(1): 40-46. DOI: 10.7555/JBR.30.20150169
    [8]Jiawei Liao, Wei Huang, George Liu. Animal models of coronary heart disease[J]. The Journal of Biomedical Research, 2017, 31(1): 3-10. DOI: 10.7555/JBR.30.20150051
    [9]Xiao-Bing Cui, Shi-You Chen. White adipose tissue browning and obesity[J]. The Journal of Biomedical Research, 2017, 31(1): 1-2. DOI: 10.7555/JBR.31.20160101
    [10]Asim Shabbir, Dallan Dargan. The success of sleeve gastrectomy in the management of metabolic syndrome and obesity[J]. The Journal of Biomedical Research, 2015, 29(2): 93-97. DOI: 10.7555/JBR.28.20140107

Catalog

    Article Metrics

    Article views (6625) PDF downloads (3171) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return