Department of Nursing, Jiangsu Jiankang Vocational University, Nanjing, Jiangsu 210029, China
2.
Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 211166, China
Funds:
This work was supported, in part, by grants from
the Natural Science Foundation of China (81402550),
the Natural Science Foundation of Jiangsu Province
(BK20140906), the Natural Science Foundation of
Jiangsu Higher Education Institutions (14KJB310007),
and the Science & Technology Development Foundation of Nanjing Medical University (2013NJMU015).
Wenping Xu received funding from Jiangsu Jiankang
Vocational University (JK201405)
Liver injury represents a continuum of pathophysiological processes involving a complex interplay between
hepatocytes, macrophages, and hepatic stellate cells. The mechanism whereby these intercellular interactions
contribute to liver injury and fibrosis is not completely understood. We report here that angiogenic factor with G patch
and FHA domains 1 (Aggf1) was downregulated in the livers of cirrhotic patients compared to healthy controls and in
primary hepatocytes in response to carbon tetrachloride (CCl4) stimulation. Overexpression of Aggf1 attenuated
macrophage chemotaxis. Aggf1 interacted with NF-κB to block its binding to the Ccl2 gene promoter and repressed
Ccl2 transcription in hepatocytes. Macrophages cultured in the conditioned media collected from Aggf1-
overexpressing hepatocytes antagonized HSC activation. Taken together, our data illustrate a novel role for Aggf1 in
regulating hepatic inflammation and provide insights on the development of interventional strategies against cirrhosis.
Tazesh S, Tamizi E, Siahi Shadbad M, et al. Comparative Stability of Two Anti-hyperpigmentation Agents: Kojic Acid as a Natural Metabolite and Its Di-Palmitate Ester, Under Oxidative Stress; Application to Pharmaceutical Formulation Design. Adv Pharm Bull, 2022, 12(2): 329-335.
DOI:10.34172/apb.2022.031