Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice

Minbo Zang; Qiao Zhou; Yunfei Zhu; Mingxi Liu; Zuomin Zhou

doi:10.7555/JBR.31.20170023

Volume 32 Issue 6

Oct. 2018

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The Journal of Biomedical Research > 2018 > 32(6): 442-453. > DOI: 10.7555/JBR.31.20170023

Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023

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Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice

State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

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Received Date: February 09, 2017
Revised Date: February 16, 2017

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Abstract

Abstract

Non-Hodgkin lymphoma (NHL) is one of the most common cancers affecting men of reproductive age. The high response rate of bendamustine as first-line reatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim was to determine the effects of bendamustine on male reproduction by animal model. Male mice were treated with bendamustine (40 mg/kg) through tail vein injection while cisplatin was given as a standard (3 mg/kg) through intraperitoneal injection. After 3 weeks, bendamustine induced weight loss and sperm morphology abnormalities were compared to the control. Additionally, sperm with folded tails were the most frequent abnormality in bendamustine-treated mice. But the mechanism of sperm abnormality induced by bendamustine remains to bevelucidated. These results indicate bendamustine may affect sprmatozoa of patients who have been treated for NHL.
- Non-Hodgkin lymphoma,
- chemotherapy,
- bendamustine,
- mice,
- spermatozoa,
- toxicology

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