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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 5
Aug.  2016
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Dongsheng Gu, Kelly E Schlotman, Jingwu Xie. Deciphering the role of hedgehog signaling in pancreatic cancer[J]. The Journal of Biomedical Research, 2016, 30(5): 353-360. DOI: 10.7555/JBR.30.20150107
Citation: Dongsheng Gu, Kelly E Schlotman, Jingwu Xie. Deciphering the role of hedgehog signaling in pancreatic cancer[J]. The Journal of Biomedical Research, 2016, 30(5): 353-360. DOI: 10.7555/JBR.30.20150107
shu

Deciphering the role of hedgehog signaling in pancreatic cancer

  • 1.

    Wells Center for Pediatric Research, Division of Hematology and Oncology, Department of Pediatrics, Indiana University Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA

  • 2.

    Wells Center for Pediatric Research, Division of Hematology and Oncology, Department of Pediatrics, Indiana University Simon Cancer Center, Indiana University, Indianapolis, IN 46203, USA

Funds: 

the National Cancer Institute CA155086,Riley Children’s Foundation, Jeff Gurdon Children’s Research Foundation and Wells Center for Pediatric Research

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  • Received Date: October 09, 2015
    Graphical Abstract
    • Abstract
  • Pancreatic cancer, mostly pancreatic ductal adenocarcinoma (PDAC), is a leading cause of cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer. Although a number of genetic changes have been identified in pancreatic cancer, their mechanisms of action in tumor development, progression and metastasis are not completely understood. Hedgehog signaling, which plays a major role in embryonic development and stem cell regulation, is known to be activated in pancreatic cancer; however, specific inhibitors targeting the smoothened molecule failed to improve the condition of pancreatic cancer patients in clinical trials. Furthermore, results regarding the role of Hh signaling in pancreatic cancer are controversial with some reporting tumor promoting activities whereas others tumor suppressive actions. In this review, we will summarize what we know about hedgehog signaling in pancreatic cancer, and try to explain the contradicting roles of hedgehog signaling as well as the reason(s) behind the failed clinical trials. In addition to the canonical hedgehog signaling, we will also discuss several non-canonical hedgehog signaling mechanisms.
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