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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 25 Issue 6
Oct.  2011
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Article Contents
Abstract
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Mani Udayakumar, Palaniyandi Shanmuga-priya, Kamalakannan Hemavathi, Rengasamy Seenivasagam. Active motif finder - a bio-tool based on mutational structures in DNA sequences[J]. The Journal of Biomedical Research, 2011, 25(6): 444-448. DOI: 10.1016/S1674-8301(11)60059-6
Citation: Mani Udayakumar, Palaniyandi Shanmuga-priya, Kamalakannan Hemavathi, Rengasamy Seenivasagam. Active motif finder - a bio-tool based on mutational structures in DNA sequences[J]. The Journal of Biomedical Research, 2011, 25(6): 444-448. DOI: 10.1016/S1674-8301(11)60059-6
shu

Active motif finder - a bio-tool based on mutational structures in DNA sequences

  • 1.

    Department of Bioinformatics, Shanmugha Arts Science Technology & Research Academy (SASTRA University), Tanjore, Tamilnadu 613402, India

  • 2.

    Department of Bioinformatics, School of Chemical and Biotechnology, Shanmugha Arts Science Technology & Research Academy (SASTRA University), Tanjore, Tamilnadu 613402, India

  • 3.

    Division of Drug Discovery and Development, Centre of Molecular and Computational Biology, Department of Botany, St. Joseph College, Bangalore, Karnataka 560027, India.

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  • Received Date: July 05, 2011
    Graphical Abstract
    • Abstract
  • Active Motif Finder (AMF) is a novel algorithmic tool, designed based on mutations in DNA sequences. Tools available at present for finding motifs are based on matching a given motif in the query sequence. AMF describes a new algorithm that identifies the occurrences of patterns which possess all kinds of mutations like insertion, de-letion and mismatch. The algorithm is mainly based on the Alignment Score Matrix (ASM) computation by com-paring input motif with full length sequence. Much of the effort in bioinformatics is directed to identify these mo-tifs in the sequences of newly discovered genes. The proposed bio-tool serves as an open resource for analysis and useful for studying polymorphisms in DNA sequences. AMF can be searched via a user-friendly interface. This tool is intended to serve the scientific community working in the areas of chemical and structural biology, and is freely available to all users, at http://www.sastra.edu/scbt/amf/.
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