4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Guangbo Fu, Jialin Tang, Meilin Wang, Chao Qin, Fu Yan, Qi Ding, Changjun Yin, Xinru Wang, Zhengdong Zhang. CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men[J]. The Journal of Biomedical Research, 2011, 25(2): 128-134. DOI: 10.1016/S1674-8301(11)60016-X
Citation: Guangbo Fu, Jialin Tang, Meilin Wang, Chao Qin, Fu Yan, Qi Ding, Changjun Yin, Xinru Wang, Zhengdong Zhang. CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men[J]. The Journal of Biomedical Research, 2011, 25(2): 128-134. DOI: 10.1016/S1674-8301(11)60016-X

CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men

Funds: 

This study was partly supported by National Natural Science Foun-dation of China (No. 30872084 and No. 30972444), the Key Program for Basic Research of Jiangsu Provincial Department of Education (No. 08KJA330001) and "Qinglan Project" Foundation for the Y

More Information
  • Caspase-8 (CASP8) plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region associated with prostate cancer risk in a hospital-based cohort of 406 Chinese prostate cancer patients and 408 age-matched cancer-free controls. Additionally,23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio (OR)=0.68; 95% confidence interval (CI)=0.51-0.92] and del/del genotype (OR=0.34; 95% CI=0.19-0.63) compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk (Ptrend = 0.001). RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ins genotype (P =0.024). These findings suggested that the CASP8 -652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.
  • Related Articles

    [1]Izzatullo Ziyoyiddin o`g`li Abdullaev, Ulugbek Gapparjanovich Gayibov, Sirojiddin Zoirovich Omonturdiev, Sobirova Fotima Azamjonovna, Sabina Narimanovna Gayibova, Takhir Fatikhovich Aripov. Molecular pathways in cardiovascular disease under hypoxia: Mechanisms, biomarkers, and therapeutic targets[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240387
    [2]Jubiao Zhang, Yang Chen, Lihong Yan, Xin Zhang, Xiaoyan Zheng, Junxia Qi, Fen Yang, Juxue Li. EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice[J]. The Journal of Biomedical Research, 2023, 37(3): 179-193. DOI: 10.7555/JBR.36.20220168
    [3]Marta Obara-Michlewska. The contribution of astrocytes to obesity-associated metabolic disturbances[J]. The Journal of Biomedical Research, 2022, 36(5): 299-311. DOI: 10.7555/JBR.36.20200020
    [4]Wang Lei, Zhang Kun, Ding Xin, Wang Yan, Bai Hui, Yang Qing, Ben Jingjing, Zhang Hanwen, Li Xiaoyu, Chen Qi, Zhu Xudong. Fucoidan antagonizes diet-induced obesity and inflammation in mice[J]. The Journal of Biomedical Research, 2021, 35(3): 197-205. DOI: 10.7555/JBR.34.20200153
    [5]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [6]Kyriakos E. Kypreos, Eleni A. Karavia, Caterina Constantinou, Aikaterini Hatziri, Christina Kalogeropoulou, Eva Xepapadaki, Evangelia Zvintzou. Apolipoprotein E in diet-induced obesity: a paradigm shift from conventional perception[J]. The Journal of Biomedical Research, 2018, 32(3): 183-190. DOI: 10.7555/JBR.32.20180007
    [7]Xiaoyang Liu, Chunlin Zheng, Cheng Xu, Qian Liu, Jin Wang, Yongzhi Hong, Peng Zhao. Nighttime snacking is associated with risk of obesity and hyperglycemia in adults: a cross-sectional survey from Chinese adult teachers[J]. The Journal of Biomedical Research, 2017, 31(6): 541-547. DOI: 10.7555/JBR.31.20160083
    [8]Celia Aradillas-García, Miguel Cruz, Elva Pérez-Luque, María E. Garay-Sevilla, Juan M. Malacara, Aduna R, Jesús Peralta, Ana Burguete-García, Jorge A. Alegría-Torres. Obesity is associated with the Arg389Gly ADRB1 but not with the Trp64Arg ADRB3 polymorphism in children from San Luis Potosí and León, México[J]. The Journal of Biomedical Research, 2017, 31(1): 40-46. DOI: 10.7555/JBR.30.20150169
    [9]Jiawei Liao, Wei Huang, George Liu. Animal models of coronary heart disease[J]. The Journal of Biomedical Research, 2017, 31(1): 3-10. DOI: 10.7555/JBR.30.20150051
    [10]Asim Shabbir, Dallan Dargan. The success of sleeve gastrectomy in the management of metabolic syndrome and obesity[J]. The Journal of Biomedical Research, 2015, 29(2): 93-97. DOI: 10.7555/JBR.28.20140107

Catalog

    Article Metrics

    Article views (3867) PDF downloads (1270) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return