4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Keh-Dong Shiang, Fouad Kandeel. A computational model of the human glucose-insulin regulatory system[J]. The Journal of Biomedical Research, 2010, 24(5): 347-364. DOI: 10.1016/S1674-8301(10)60048-6
Citation: Keh-Dong Shiang, Fouad Kandeel. A computational model of the human glucose-insulin regulatory system[J]. The Journal of Biomedical Research, 2010, 24(5): 347-364. DOI: 10.1016/S1674-8301(10)60048-6

A computational model of the human glucose-insulin regulatory system

Funds: 

This study was supported by a grant from the NIH (No. U42 RR 16607)

More Information
  • Received Date: August 02, 2010
  • Objective: A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The proposed method for the estimation of parameters for a system of ordinary differential equations (ODEs) that represent the time course of plasma glucose and insulin concentrations during glucose tolerance test (GTT) in physiological studies is presented. The aim of this study was to explore how to interpret those laboratory glucose and insulin data as well as enhance the Ackerman math-ematical model. Methods: Parameters estimation for a system of ODEs was performed by minimizing the sum of squared residuals (SSR) function, which quantifies the difference between theoretical model predictions and GTT's experimental observations. Our proposed perturbation search and multiple-shooting methods were applied during the estimating process. Results: Based on the Ackerman's published data, we estimated the key param-eters by applying R-based iterative computer programs. As a result, the theoretically simulated curves perfectly matched the experimental data points. Our model showed that the estimated parameters, computed frequency and period values, were proven a good indicator of diabetes. Conclusion: The present paper introduces a computational algorithm to biomedical problems, particularly to endocrinology and metabolism fields, which involves two coupled differential equations with four parameters describing the glucose-insulin regulatory system that Acker-man proposed earlier. The enhanced approach may provide clinicians in endocrinology and metabolism field in-sight into the transition nature of human metabolic mechanism from normal to impaired glucose tolerance.
  • Related Articles

    [1]Izzatullo Ziyoyiddin o`g`li Abdullaev, Ulugbek Gapparjanovich Gayibov, Sirojiddin Zoirovich Omonturdiev, Sobirova Fotima Azamjonovna, Sabina Narimanovna Gayibova, Takhir Fatikhovich Aripov. Molecular pathways in cardiovascular disease under hypoxia: Mechanisms, biomarkers, and therapeutic targets[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240387
    [2]Hui Wang, Qian Zhang, Yuankai Sun, Wenfeng Tan, Miaojia Zhang. AdipoR1 promotes pathogenic Th17 differentiation by regulating mitochondrial function through FUNDC1[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240244
    [3]Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
    [4]Huan Liu, Shijiang Zhang, Yongfeng Shao, Xiaohu Lu, Weidong Gu, Buqing Ni, Qun Gu, Junjie Du. Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis[J]. The Journal of Biomedical Research, 2018, 32(6): 454-460. DOI: 10.7555/JBR.31.20170011
    [5]Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023
    [6]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [7]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [8]Xiaoyan Qu, Lijuan Chen, Tian Tian, Limin Duan, Ruinan Lu, Hua Lu, Hanxin Wu, Jianyong Li. Clinical features of multiple myeloma patients with isolated extramedullary relapse[J]. The Journal of Biomedical Research, 2018, 32(4): 264-269. DOI: 10.7555/JBR.31.20140090
    [9]Eva Baranovicova, Ema Kantorova, Dagmar Kalenska, Lucia Lichardusova, Michal Bittsan- sky, Dusan Dobrota. Thalamic paramagnetic iron by T2* relaxometry correlates with severity of multiple sclerosis[J]. The Journal of Biomedical Research, 2017, 31(4): 301-305. DOI: 10.7555/JBR.31.20160023
    [10]Sundeep?S.?Tumber, Hong?Liu. Epidural abscess after multiple lumbar punctures for labour epidural catheter placement[J]. The Journal of Biomedical Research, 2010, 24(4): 332-335. DOI: 10.1016/S1674-8301(10)60046-2

Catalog

    Article Metrics

    Article views (3060) PDF downloads (1300) Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return