4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Hua Huang, Juan Wu, Guangfu Jin, Hanze Zhang, Yanbing Ding, Zhaolai Hua, Yan Zhou, Yan Xue, Yan Lu, Zhibin Hu, Yaochu Xu, Hongbing Shen. A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population[J]. The Journal of Biomedical Research, 2010, 24(2): 100-106.
Citation: Hua Huang, Juan Wu, Guangfu Jin, Hanze Zhang, Yanbing Ding, Zhaolai Hua, Yan Zhou, Yan Xue, Yan Lu, Zhibin Hu, Yaochu Xu, Hongbing Shen. A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population[J]. The Journal of Biomedical Research, 2010, 24(2): 100-106.

A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population

Funds: 

This study was supported in part by National Natural Science Foundation of China (30700684 and 30671814), Jiangsu Natural Science Foundation (BK2008221) and the Key Project of Nanjing Medical University (09NJMUZ12)

More Information
  • Received Date: January 04, 2010
  • Objective: Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to gastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rs1927914 T > C and rs10759932 T > C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rs10759932 had a significantly reduced risk of gastric cancer (adjusted OR = 0.81; 95%CI = 0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity > 0.05). No significant association was observed between rs1927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings.
  • Related Articles

    [1]Siying Wang, Saiya Wang, Wenhan Cai, Jie Wang, Jianan Huang, Qing Yang, Hui Bai, Bin Jiang, Jingjing Ben, Hanwen Zhang, Xudong Zhu, Xiaoyu Li, Qi Chen. Macrophage scavenger receptor A1 promotes skeletal muscle regeneration after hindlimb ischemia[J]. The Journal of Biomedical Research, 2025, 39(1): 23-35. DOI: 10.7555/JBR.38.20240117
    [2]Mingfeng He, Chanjuan Gong, Yinan Chen, Rongting Chen, Yanning Qian. Effect of remimazolam vs. propofol on hemodynamics during general anesthesia induction in elderly patients: Single-center, randomized controlled trial[J]. The Journal of Biomedical Research, 2024, 38(1): 66-75. DOI: 10.7555/JBR.37.20230110
    [3]Maglione Michele, Salvador Enrico, Ruaro Maria E., Melato Mauro, Tromba Giuliana, Angerame Daniele, Bevilacqua Lorenzo. Bone regeneration with adipose derived stem cells in a rabbit model[J]. The Journal of Biomedical Research, 2019, 33(1): 38-45. DOI: 10.7555/JBR.32.20160066
    [4]Park Gi Young, Kwon Dong Rak, Moon Yong Suk. Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits[J]. The Journal of Biomedical Research, 2019, 33(1): 30-37. DOI: 10.7555/JBR.32.20180056
    [5]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [6]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [7]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [8]Bing Zhang, Ling Ni, Fangfang Wang, Weiping Li, Xin Zhang, Xiaohua Gu, Zuzana Nedelska, Fei Chen, Kun Wang, Bin Zhu, Renyuan Liu, Jun Xu, Jinfan Wang. Effective doctor-patient communication skills training optimizes functional organization of intrinsic brain architecture: a restingstate functional MRI study[J]. The Journal of Biomedical Research, 2017, 31(6): 486-493. DOI: 10.7555/JBR.31.20160135
    [9]Kieran Walsh. Cost and value in medical education: the role of statistical process control[J]. The Journal of Biomedical Research, 2017, 31(4): 277-278. DOI: 10.7555/JBR.31.20160086
    [10]Jian Li, Chaonong Cai, Hui Guo, Xiaodong Guan, Lukun Yang, Yuechan Li, Yanhua Zhu, Peiping Li, Xialei Liu, Baimeng Zhang. Portal vein arterialization promotes liver regeneration after extended partial hepatectomy in a rat model[J]. The Journal of Biomedical Research, 2015, 29(1): 69-75. DOI: 10.7555/JBR.29.20140054

Catalog

    Article Metrics

    Article views PDF downloads Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return