Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

Park Gi Young; Kwon Dong Rak; Moon Yong Suk

doi:10.7555/JBR.32.20180056

Volume 33 Issue 1

Dec. 2018

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The Journal of Biomedical Research > 2019 > 33(1): 30-37. > DOI: 10.7555/JBR.32.20180056

Park Gi Young, Kwon Dong Rak, Moon Yong Suk. Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits[J]. The Journal of Biomedical Research, 2019, 33(1): 30-37. DOI: 10.7555/JBR.32.20180056

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Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

1.
Department of Rehabilitation Medicine, Muscle Research Center, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea
2.
Department of Anatomy, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea

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Corresponding author:
Dong Rak Kwon, M.D., Ph.D., Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-Gu, Daegu 42472, Republic of Korea. Tel/Fax:+ 82-53-650-3627/+ 82-53-622-4687, E-mail: coolkwon@cu.ac.kr or dongrakkwon@hotmail.com
Received Date: June 13, 2018
Revised Date: June 24, 2018
Accepted Date: July 04, 2018
Available Online: August 19, 2018

Graphical Abstract

Abstract

Abstract

The purpose of this study was to investigate the intensity-specific regenerative effects of microcurrent therapy on gastrocnemius muscle atrophy induced by cast-immobilization in rabbits. Fifteen rabbits were randomly allocated to 3 groups after cast removal: cast-immobilization and sham microcurrent therapy for 2 weeks (group 1); castimmobilization and microcurrent therapy (25 μA) for 2 weeks (group 2); cast-immobilization and microcurrent therapy (5, 000 μA) for 2 weeks (group 3). Clinical parameters [calf circumference, compound muscle action potential (CMAP) of the tibial nerve, thickness of gastrocnemius muscle], cross sectional area of gastrocnemius muscle fibres, and immunohistochemistry was evaluated. The clinical parameters representing mean atrophic changes in group 2 were significantly lower than those in group 3. The cross sectional area of the gastrocnemius muscle fibres and immunohistochemical parameters in group 2 were significantly greater than those in group 3. The results showed that low-intensity microcurrent therapy can more effectively promote regeneration in atrophied gastrocnemius muscle than high-intensity microcurrent therapy.
- microcurrent,
- intensity,
- atrophy,
- muscle,
- cast

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education (NRF-2016R1D1A1B01014260).

References (30)

References

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Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

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