4.6
CiteScore
2.2
Impact Factor
- ISSN 1674-8301
- CN 32-1810/R
4.6
2.2
| Citation: |
Yue Xiao, Yue Peng, Chi Zhang, Wei Liu, Kehan Wang, Jing Li. hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice[J]. The Journal of Biomedical Research, 2023, 37(5): 382-393. DOI: 10.7555/JBR.36.20220166
|
Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs, such as cisplatin. Various fertility preservation methods have been explored for women, especially prepubertal girls undergoing radiotherapy and chemotherapy due to cancer. In recent years, mesenchymal stem cell-derived exosomes (MSC-exos) have been reported to play an important role in tissue repair and the treatment of various diseases. In the current study, we observed that human umbilical cord-derived MSC-exos (hucMSC-exos) after short-term culture improved follicular survival and development while receiving cisplatin treatment. Moreover, intravenous injection of hucMSC-exos improved ovarian function and ameliorated inflammatory environment within the ovary. The underlying mechanism of hucMSC-exos on fertility preservation was associated with the down-regulation of p53-related apoptosis and their anti-inflammatory function. Based on these findings, we propose that hucMSC-exos may be a potential approach to improve fertility in women diagnosed with cancer.
This work is supported by the National Key Research and Development Program of China (Grant Nos. 2018YFC1003703 and 2018YFC1004203) and the National Natural Science Foundation of China (Grant No. 31871513).
CLC number: R711.75; R730.53, Document code: A
The authors reported no conflict of interests.
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| 1. | Firouzabadi SR, Mohammadi I, Ghafourian K, et al. Mesenchymal stem cell-derived extracellular vesicles therapy for primary ovarian insufficiency: a systematic review and meta-analysis of pre-clinical studies. J Ovarian Res, 2024, 17(1): 200. DOI:10.1186/s13048-024-01513-1 |
| 2. | Guan CY, Zhang D, Sun XC, et al. hUC-MSC Combined with DHEA Alleviates Ovarian Senescence in Naturally Aging Mice through Enhancing Antioxidant Capacity and Inhibiting Inflammatory Response. Stem Cells Int, 2024, 2024: 3100942. DOI:10.1155/2024/3100942 |
| 3. | Song J, Guo X, Zhang B, et al. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Improved The Aged Mouse IVM Oocytes Quality. Reprod Sci, 2024, 31(9): 2808-2819. DOI:10.1007/s43032-024-01566-z |
| 1. | Firouzabadi SR, Mohammadi I, Ghafourian K, et al. Mesenchymal stem cell-derived extracellular vesicles therapy for primary ovarian insufficiency: a systematic review and meta-analysis of pre-clinical studies. J Ovarian Res, 2024, 17(1): 200. DOI:10.1186/s13048-024-01513-1 |
| 2. | Guan CY, Zhang D, Sun XC, et al. hUC-MSC Combined with DHEA Alleviates Ovarian Senescence in Naturally Aging Mice through Enhancing Antioxidant Capacity and Inhibiting Inflammatory Response. Stem Cells Int, 2024, 2024: 3100942. DOI:10.1155/2024/3100942 |
| 3. | Song J, Guo X, Zhang B, et al. Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Improved The Aged Mouse IVM Oocytes Quality. Reprod Sci, 2024, 31(9): 2808-2819. DOI:10.1007/s43032-024-01566-z |
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