4.6

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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 5
Aug.  2012
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Xiaozheng Zhong, Xiaoyu Li, Lingling Qian, Yiming Xu, Yan Lu, Jing Zhang, Nan Li, Xudong Zhu, Jingjing Ben, Qing Yang, Qi Chen. Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats[J]. The Journal of Biomedical Research, 2012, 26(5): 346-354. DOI: 10.7555/JBR.26.20110124
Citation: Xiaozheng Zhong, Xiaoyu Li, Lingling Qian, Yiming Xu, Yan Lu, Jing Zhang, Nan Li, Xudong Zhu, Jingjing Ben, Qing Yang, Qi Chen. Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats[J]. The Journal of Biomedical Research, 2012, 26(5): 346-354. DOI: 10.7555/JBR.26.20110124
shu

Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats

  • 1.

    Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Funds: 

National Natural Science Foundation of China (No. 81070120, 81000118 and 81100857) and the National Basic Research Program (973 Program, No. 2012CB517503 and 2011CB503903).

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    Graphical Abstract
    • Abstract
  • Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.
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