4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Zhang Lingshu, Yuan Yi, Xu Qiang, Jiang Zhengyu, Chu Cong-Qiu. Contribution of neutrophils in the pathogenesis of rheumatoid arthritis——Neutrophils in rheumatoid arthritis[J]. The Journal of Biomedical Research, 2020, 34(2): 86-93. DOI: 10.7555/JBR.33.20190075
Citation: Zhang Lingshu, Yuan Yi, Xu Qiang, Jiang Zhengyu, Chu Cong-Qiu. Contribution of neutrophils in the pathogenesis of rheumatoid arthritis——Neutrophils in rheumatoid arthritis[J]. The Journal of Biomedical Research, 2020, 34(2): 86-93. DOI: 10.7555/JBR.33.20190075

Contribution of neutrophils in the pathogenesis of rheumatoid arthritisNeutrophils in rheumatoid arthritis

  • Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.
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