Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089
Citation:
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089
Citation:
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089
Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea
Departments of Preventive Medicine and Medical Research Institute, College of Medicine
2.
Departments of Surgery, College of Medicine
3.
Departments of Internal Medicine, College of Medicine
4.
Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea
5.
Department of Surgery, College of Medicine, Eulji University, Daejon 301746, Korea
6.
Department of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul 138736, Korea
Funds:
This work was supported by the National Research Foundation of Korea Grant, funded by the Korean Government (Ministry of Education, Science and Technology) [NRF-355-2010-1-E00026 and 2012R1- A1A2044765]
There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.
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