4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089
Citation: Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, SeiJin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim. Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea[J]. The Journal of Biomedical Research, 2018, 32(4): 257-263. DOI: 10.7555/JBR.32.20170089

Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

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This work was supported by the National Research Foundation of Korea Grant, funded by the Korean Government (Ministry of Education, Science and Technology) [NRF-355-2010-1-E00026 and 2012R1- A1A2044765]

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  • Received Date: August 07, 2017
  • Revised Date: November 08, 2017
  • There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.
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    1. Guan M, Wang Y. Common variants of vitamin D receptor gene polymorphisms and risk of gastric cancer: A meta-analysis. Medicine (Baltimore), 2024, 103(35): e39527. DOI:10.1097/MD.0000000000039527
    2. Abo-Amer YE, Mohamed AA, Elhoseeny MM, et al. Association Between Vitamin D Receptor Polymorphism and the Response to Helicobacter Pylori Treatment. Infect Drug Resist, 2023, 16: 4463-4469. DOI:10.2147/IDR.S414186
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    4. Nguyen MT, Huynh NNY, Nguyen DD, et al. Vitamin D intake and gastric cancer in Viet Nam: a case-control study. BMC Cancer, 2022, 22(1): 838. DOI:10.1186/s12885-022-09933-2
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    6. Durak Ş, Gheybi A, Demirkol Ş, et al. The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer. Mol Biol Rep, 2019, 46(6): 6413-6420. DOI:10.1007/s11033-019-05088-9
    7. Kazemian E, Akbari ME, Moradi N, et al. Vitamin D Receptor Genetic Variation and Cancer Biomarkers among Breast Cancer Patients Supplemented with Vitamin D3: A Single-Arm Non-Randomized Before and After Trial. Nutrients, 2019, 11(6): 1264. DOI:10.3390/nu11061264
    8. Cai H, Jing C, Chang X, et al. Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing. J Transl Med, 2019, 17(1): 189. DOI:10.1186/s12967-019-1941-0

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