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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 1
Jan.  2021
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Article Contents
Abstract
References
Qiu Jinchun, Guo Hongli, Li Ling, Xu Zeyue, Xu Zejun, Jing Xia, Hu Yahui, Wen Xiaoyi, Chen Feng, Lu Xiaopeng. Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy— a pilot longitudinal study[J]. The Journal of Biomedical Research, 2021, 35(1): 61-67. DOI: 10.7555/JBR.34.20200057
Citation: Qiu Jinchun, Guo Hongli, Li Ling, Xu Zeyue, Xu Zejun, Jing Xia, Hu Yahui, Wen Xiaoyi, Chen Feng, Lu Xiaopeng. Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy— a pilot longitudinal study[J]. The Journal of Biomedical Research, 2021, 35(1): 61-67. DOI: 10.7555/JBR.34.20200057
shu

Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy— a pilot longitudinal study

  • 1.

    Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China

  • 2.

    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China

  • 3.

    Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China

More Information
  • Corresponding author:

    Feng Chen, Department of Pharmacy, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Tel: +86-25-83117210, E-mail: cy.chen508@gmail.com

    Xiaopeng Lu, Department of Neurology, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Tel: +86-25-83116827, E-mail: lxp20071113@sina.com

  • Received Date: April 22, 2020
  • Revised Date: September 21, 2020
  • Accepted Date: September 23, 2020
  • Available Online: November 19, 2020
    Graphical Abstract
    • Abstract
  • To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA. Blood levels of calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D [25(OH)D] and plasma VPA level were measured at 1- to 3-month intervals. At the initial and final measurements, vitamin D deficiency or insufficiency was recognized in 8 (32%) and 12 (42%), respectively. In girls, a decreasing trend in serum 25(OH)D levels (P<0.05) was observed. Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D (P<0.05) in girls. In conclusion, our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D.
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  • ΔThese authors contributed equally to this work.

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    2. Shnayder NA, Grechkina VV, Trefilova VV, et al. Valproate-Induced Metabolic Syndrome. Biomedicines, 2023, 11(5): 1499. DOI:10.3390/biomedicines11051499
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