Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with
metabolic syndrome in a Chinese community-based population
of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103
Citation:
Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with
metabolic syndrome in a Chinese community-based population
of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103
Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with
metabolic syndrome in a Chinese community-based population
of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103
Citation:
Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with
metabolic syndrome in a Chinese community-based population
of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103
Elevated thyroid stimulating hormone levels are associated with
metabolic syndrome in a Chinese community-based population
of euthyroid people aged 40 years and older
This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in
euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years
old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within
the normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50
mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC),
low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group
and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of central
obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) was
significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the
high-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of
metabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. In
conclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old.
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