4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103
Citation: Bojin Xu, Hui Yang, Zhixiao Wang, Tao Yang, Hongwei Guo, Pei Cheng, Wei He, Min Sun, Huanhuan Chen, Yu Duan. Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older[J]. The Journal of Biomedical Research, 2016, 30(6): 476-482. DOI: 10.7555/JBR.30.20150103

Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older

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the Chinese Society of Endocrinology and National Clinical Research Center for Metabolic Diseases (81170726)

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  • Received Date: July 17, 2015
  • Revised Date: October 04, 2015
  • This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 years old) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50 mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of central obesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in the high-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. In conclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old.
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