4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Wenhua Xu, Mingfang Li, Minglong Chen, Bing Yang, Daowu Wang, Xiangqing Kong, Hongwu Chen, Weizhu Ju, Kai Gu, Kejiang Cao, Hailei Liu, Qi Jiang, Jiaojiao Shi, Yan Cui, Hong Wang. Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor[J]. The Journal of Biomedical Research, 2015, 29(6): 465-474. DOI: 10.7555/JBR.29.20150032
Citation: Wenhua Xu, Mingfang Li, Minglong Chen, Bing Yang, Daowu Wang, Xiangqing Kong, Hongwu Chen, Weizhu Ju, Kai Gu, Kejiang Cao, Hailei Liu, Qi Jiang, Jiaojiao Shi, Yan Cui, Hong Wang. Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor[J]. The Journal of Biomedical Research, 2015, 29(6): 465-474. DOI: 10.7555/JBR.29.20150032

Effect of burden and origin sites of premature ventricular contractions on left ventricular function by 7-day Holter monitor

Funds: 

the innovation project in Jiangsu province, China, and the Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU (IRT-004)

More Information
  • Received Date: March 01, 2015
  • Revised Date: March 01, 2015
  • Recent studies have shown that premature ventricular contractions (PVCs) could enlarge the heart, but its risk factors are incompletely understood as a single 24-hour recording cannot reflect the true PVC burden due to day-to-day variability. Our purpose was to investigate the effect of burden and origin sites on left ventricular (LV) function in patients with PVCs by 7-day Holter electrocardiography (ECG). From May 2012 to August 2013, 112 consecutive patients with PVCs were recruited from the authors’ affiliated hospital. All patients received 2-dimensional transthoracic echocardiography, 12-lead routing ECG and 7-days Holter ECG. Serum N-terminal probrain natriuretic peptide (NT-proBNP) levels were measured. A total of 102 participants with PVCs were included in the final analysis. Origin of PVCs from the tricuspid annulus had the highest burden and NT-proBNP level. LV papillary muscle had a higher LV ejection fraction (EF) level and a lower LV end-systolic dimension (ESD) than other PVC foci (P,0.05). The high burden group had a higher LV end-diastolic dimension (EDD) and LVESD but lower LVEF than the other two groups (P,0.05). Female, older age, physical work, and history of PVCs had a significantly positive correlation with symptoms. Male, older age,physical work, and high burden were positive predictors of enlarged LVEDD, LVESD and higher serum NT-proBNP level, but lower LVEF. Seven-day dynamic ECG Holter monitor showed the true PVC burden on patients with PVCs. PVCs with a lower burden or origin from the LV papillary muscle and the fascicle were relatively benign, while PVCs with a higher burden or origin from the tricuspid annulus may lead to cardiac dysfunction.
  • Related Articles

    [1]Chanjuan Gong, Xiaokai Zhou, Yin Fang, Yanjuan Zhang, Linjia Zhu, Zhengnian Ding. Effects of sevoflurane on left ventricular function by speckle-tracking echocardiography in coronary bypass patients: A randomized trial[J]. The Journal of Biomedical Research, 2024, 38(1): 76-86. DOI: 10.7555/JBR.37.20230173
    [2]Mingfeng He, Chanjuan Gong, Yinan Chen, Rongting Chen, Yanning Qian. Effect of remimazolam vs. propofol on hemodynamics during general anesthesia induction in elderly patients: Single-center, randomized controlled trial[J]. The Journal of Biomedical Research, 2024, 38(1): 66-75. DOI: 10.7555/JBR.37.20230110
    [3]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [4]Minglong Chen. Ventricular tachycardia ablation and substrate modification in ICD patients with electrical storm[J]. The Journal of Biomedical Research, 2015, 29(1): 52-55. DOI: 10.7555/JBR.29.20140165
    [5]Akihiko Nogami. Trigger elimination of polymorphic ventricular tachycardia and ventricular fibrillation by catheter ablation: trigger and substrate modification[J]. The Journal of Biomedical Research, 2015, 29(1): 44-51. DOI: 10.7555/JBR.29.20140156
    [6]Zhiyong Qian, Jianghong Guo, Zhiyong Zhang, Yao Wang, Xiaofeng Hou, Jiangang Zou. Optimal programming management of ventricular tachycardia storm in ICD patients[J]. The Journal of Biomedical Research, 2015, 29(1): 35-43. DOI: 10.7555/JBR.29.20140146
    [7]Wei Qin, Liming Wang, Xin Chen, Peisheng Liu, Rui Wang. Left ventricular myxoma: a case report[J]. The Journal of Biomedical Research, 2014, 28(6): 506-508. DOI: 10.7555/JBR.28.20120124
    [8]Weihua Zhou, Ji Chen. I -123 metaiodobenzylguanidine imaging for predicting ventricular arrhythmia in heart failure patients[J]. The Journal of Biomedical Research, 2013, 27(6): 460-466. DOI: 10.7555/JBR.27.20130137
    [9]Chunyan Cheng, Yuan Lin, Fan Yang, Wenjing Wang, Chong Wu, Jingli Qin, Xiuqin Shao, Lei Zhou. Mutational screening of affected cardiac tissues and peripheral blood cells identified novel somatic mutations in GATA4 in patients with ventricular septal defect[J]. The Journal of Biomedical Research, 2011, 25(6): 425-430. DOI: 10.1016/S1674-8301(11)60056-0
    [10]Zhao Zhao, Zuyi Yuan, Yuqiang Ji, Yue Wu, Yinzhi Qi. Left ventricular hypertrophy amplifies the QT, and Tp-e intervals and the Tp-e/ QT ratio of left chest ECG[J]. The Journal of Biomedical Research, 2010, 24(1): 69-72.
  • Cited by

    Periodical cited type(1)

    1. Shen Q, Li J, Cui C, et al. A wearable real-time telemonitoring electrocardiogram device compared with traditional Holter monitoring. J Biomed Res, 2020, 35(3): 238-246. DOI:10.7555/JBR.34.20200074

    Other cited types(0)

Catalog

    Article Metrics

    Article views (3216) PDF downloads (561) Cited by(1)
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return