Shaoli Wang, Jingyun Zhang, Tao Sheng, Wei Lu, Dengshun Miao. Hippocampal ischemia causes deficits in local field potential and
synaptic plasticity[J]. The Journal of Biomedical Research, 2015, 29(5): 370-379. DOI: 10.7555/JBR.29.20150010
Citation:
Shaoli Wang, Jingyun Zhang, Tao Sheng, Wei Lu, Dengshun Miao. Hippocampal ischemia causes deficits in local field potential and
synaptic plasticity[J]. The Journal of Biomedical Research, 2015, 29(5): 370-379. DOI: 10.7555/JBR.29.20150010
Shaoli Wang, Jingyun Zhang, Tao Sheng, Wei Lu, Dengshun Miao. Hippocampal ischemia causes deficits in local field potential and
synaptic plasticity[J]. The Journal of Biomedical Research, 2015, 29(5): 370-379. DOI: 10.7555/JBR.29.20150010
Citation:
Shaoli Wang, Jingyun Zhang, Tao Sheng, Wei Lu, Dengshun Miao. Hippocampal ischemia causes deficits in local field potential and
synaptic plasticity[J]. The Journal of Biomedical Research, 2015, 29(5): 370-379. DOI: 10.7555/JBR.29.20150010
The long-term enhancement in glutamate receptor mediated excitatory responses has been observed in
stroke model. This pathological form of plasticity, termed post-ischemic long-term potentiation (i-LTP), points to
functional reorganization after stroke. Little is known, however, about whether and how this i-LTP would
affect subsequent induction of synaptic plasticity. Here, we first directly confirmed that i-LTP was induced in the
endothelin-1-induced ischemia model as in other in vitro models. We also demonstrated increased expression of
NR2B, CaMKII and p-CaMKII, which are reminiscent of i-LTP. We further induced LTP of field excitatory postsynaptic
potentials (fEPSPs) on CA1 hippocampal neurons in peri-infarct regions of the endothelin-1-induced
mini-stroke model. We found that LTP of fEPSPs, induced by high-frequency stimulation, displayed a progressive
impairment at 12 and 24 hours after ischemia. Moreover, using in vivo multi-channel recording, we found that the
local field potential, which represents electrical property of cell ensembles in more restricted regions, was also dampened
at these two time points. These results suggest that i-LTP elevates the induction threshold of subsequent synaptic
plasticity. Our data helps to deepen the knowledge of meta-synaptic regulation of plasticity after focal ischemia.
Langyan S, Bhardwaj R, Kumari J, et al. Nutritional Diversity in Native Germplasm of Maize Collected From Three Different Fragile Ecosystems of India. Front Nutr, 2022, 9: 812599.
DOI:10.3389/fnut.2022.812599
2.
Juvinao-Quintero DL, Cardenas A, Perron P, et al. Associations between an integrated component of maternal glycemic regulation in pregnancy and cord blood DNA methylation. Epigenomics, 2021, 13(18): 1459-1472.
DOI:10.2217/epi-2021-0220
3.
Zhang J, Wu X. Predict Health Care Accessibility for Texas Medicaid Gap. Healthcare (Basel), 2021, 9(9): 1214.
DOI:10.3390/healthcare9091214
4.
Ayati M, Koyutürk M. PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases. PLoS Comput Biol, 2016, 12(11): e1005195.
DOI:10.1371/journal.pcbi.1005195
5.
Zhang Q, Zhao Y, Zhang R, et al. A Comparative Study of Five Association Tests Based on CpG Set for Epigenome-Wide Association Studies. PLoS One, 2016, 11(6): e0156895.
DOI:10.1371/journal.pone.0156895