4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 28 Issue 5
Aug.  2014
Turn off MathJax
Article Contents
Abstract
Related Articles
Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. DOI: 10.7555/JBR.28.20140015
Citation: Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. DOI: 10.7555/JBR.28.20140015
shu

AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

  • 1.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

  • 2.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710062, China.

  • 3.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710063, China.

  • 4.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710064, China.

  • 5.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710065, China.

  • 6.

    Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710066, China.

More Information
  • Received Date: February 07, 2014
  • Revised Date: February 27, 2014
    Graphical Abstract
    • Abstract
  • Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r50.227, P50.045), clinical stage (r50.491, P,0.001) and clinical grade (r50.450, P,0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P.0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r50.240, P 5 0.035) and PPP6c (r5 0.250, P 5 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]Yanhui Li, Yuqian Ge, Mengjie Zhao, Fangshu Ding, Xiuxing Wang, Zhumei Shi, Xin Ge, Xiefeng Wang, Xu Qian. HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas[J]. The Journal of Biomedical Research, 2023, 37(5): 326-339. DOI: 10.7555/JBR.37.20220234
    [2]Tiwari-Heckler Shilpa, Jiang Z. Gordon, Popov Yury, J. Mukamal Kenneth. Daily high-dose aspirin does not lower APRI in the Aspirin-Myocardial Infarction Study[J]. The Journal of Biomedical Research, 2020, 34(2): 139-142. DOI: 10.7555/JBR.33.20190041
    [3]Tao Chun'ai, Gan Yongxin, Su Weidong, Li Zhutian, Tang Xiaolan. Effectiveness of hospital disinfection and experience learnt from 11 years of surveillance[J]. The Journal of Biomedical Research, 2019, 33(6): 408-413. DOI: 10.7555/JBR.33.20180118
    [4]Huan Liu, Shijiang Zhang, Yongfeng Shao, Xiaohu Lu, Weidong Gu, Buqing Ni, Qun Gu, Junjie Du. Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis[J]. The Journal of Biomedical Research, 2018, 32(6): 454-460. DOI: 10.7555/JBR.31.20170011
    [5]Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023
    [6]Huanqiang Wang, Congying Yang, Siyuan Wang, Tian Wang, Jingling Han, Kai Wei, Fucun Liu, Jida Xu, Xianzhen Peng, Jianming Wang. Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer[J]. The Journal of Biomedical Research, 2018, 32(6): 424-433. DOI: 10.7555/JBR.32.20170065
    [7]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [8]Yong Ji, Mingfeng Zheng, Shugao Ye, Jingyu Chen, Yijiang Chen. PTEN and Ki67 expression is associated with clinicopathologic features of non-small cell lung cancer[J]. The Journal of Biomedical Research, 2014, 28(6): 462-467. DOI: 10.7555/JBR.27.20130084
    [9]Chen Liang, Shiwen Guo, Ling Yang. All-trans retinoic acid upregulates VEGF expression in glioma cells in vitro[J]. The Journal of Biomedical Research, 2013, 27(1): 51-55. DOI: 10.7555/JBR.27.20120048
    [10]Lihua Liu, Ming Zhang, Yuan Wang, Min Li. The relationship between the expression of tumor matrix-metalloproteinase and the characteristics of magnetic resonance imaging of human gliomas[J]. The Journal of Biomedical Research, 2010, 24(2): 124-131.

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (7008) PDF downloads (4147) Cited by()
    Related

    ©2023 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return