4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Cheng Wang, Zhengfeng Xu, Guangfu Jin, Zhibin Hu, Juncheng Dai, Hongxia Ma, Yue Jiang, Lingmin Hu, Minjie Chu, Songyu Cao, Hongbing Shen. Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese[J]. The Journal of Biomedical Research, 2013, 27(3): 208-214. DOI: 10.7555/JBR.27.20130017
Citation: Cheng Wang, Zhengfeng Xu, Guangfu Jin, Zhibin Hu, Juncheng Dai, Hongxia Ma, Yue Jiang, Lingmin Hu, Minjie Chu, Songyu Cao, Hongbing Shen. Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese[J]. The Journal of Biomedical Research, 2013, 27(3): 208-214. DOI: 10.7555/JBR.27.20130017

Genome-wide analysis of runs of homozygosity identifies new susceptibility regions of lung cancer in Han Chinese

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This work was supported in part the by National Natural Science Foundation of China (81230067, 81270044 and 30901233)

Doctoral Fund of Ministry of Education of China (20093234110001), New Century Excellent Talents in University (NCET-10-0178), and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

More Information
  • Received Date: January 12, 1931
  • Runs of homozygosity (ROHs) are a class of important but poorly studied genomic variations and may be in-volved in individual susceptibility to diseases. To better understand ROH and its relationship with lung cancer, we performed a genome-wide ROH analysis of a subset of a previous genome-wide case-control study (1,473 cases and 1,962 controls) in a Han Chinese population. ROHs were classified into two classes, based on lengths, intermedi-ate and long ROHs, to evaluate their association with lung cancer risk using existing genome-wide single nucleotide polymorphism (SNP) data. We found that the overall level of intermediate ROHs was significantly associated with a decreased risk of lung cancer (odds ratio = 0.63; 95% confidence interval: 0.51-0.77; P = 4.78×10-6 ), while the long ROHs seemed to be a risk factor of lung cancer. We also identified one ROH region at 14q23.1 that was con-sistently associated with lung cancer risk in the study. These results indicated that ROHs may be a new class of variation which may be associated with lung cancer risk, and genetic variants at 14q23.1 may be involved in the development of lung cancer.
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