4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Jiaxin Ye, Ping Ni, Lina Kang, Biao Xu. Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction[J]. The Journal of Biomedical Research, 2012, 26(6): 400-409. DOI: 10.7555/JBR.26.20120052
Citation: Jiaxin Ye, Ping Ni, Lina Kang, Biao Xu. Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction[J]. The Journal of Biomedical Research, 2012, 26(6): 400-409. DOI: 10.7555/JBR.26.20120052

Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction

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This work was supported by the program (No. CX10B_421Z to Jiaxin Ye) for Postgraduate Research Innovation in Universities of Jiangsu Province

the grants (No. 81070195) and (No. 81000055) from Chinese National Science Fund of China (all to Biao Xu), and grant (No. KF200938 to Lina Kang) from Jiangsu Province.

More Information
  • Received Date: May 14, 2012
  • This study was designed to determine the levels of early endothelial progenitor cells (EPCs), apelin, vascu-lar endothelial growth factor (VEGF) and stromal cell-derived growth factor-1 (SDF-1) after acute myocardial infarction (AMI), and to investigate the relationships between these cytokines and early EPCs. Early EPCs, de-fined as CD133+, KDR+, and CD34+ cells, were quantified by flow cytometry. The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls (P < 0.05). Plasma apelin levels were inversely correlated with Gensini score and early EPCs (both P < 0.01). Early EPCs, VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h. The trend in the change of early EPCs was proportionally correlated with that of VEGF (P < 0.05). AMI patients exhibited in-creased early EPCs with remarkably decreased apelin levels and enhanced VEGF levels.
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