4.6

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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 25 Issue 4
Jun.  2011
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Abstract
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Li Yang, Huaijun Zhu, Dongxiao Liu, Song Liang, Hao Xu, Jie Chen, Xuerong Wang, Zekuan Xu. Aspirin suppresses growth of human gastric carcinoma cell by inhibiting survivin expression[J]. The Journal of Biomedical Research, 2011, 25(4): 246-253. DOI: 10.1016/S1674-8301(11)60033-X
Citation: Li Yang, Huaijun Zhu, Dongxiao Liu, Song Liang, Hao Xu, Jie Chen, Xuerong Wang, Zekuan Xu. Aspirin suppresses growth of human gastric carcinoma cell by inhibiting survivin expression[J]. The Journal of Biomedical Research, 2011, 25(4): 246-253. DOI: 10.1016/S1674-8301(11)60033-X
shu

Aspirin suppresses growth of human gastric carcinoma cell by inhibiting survivin expression

  • 1.

    Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    Division of Clinical Pharmacy, Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, China

  • 3.

    Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Funds: 

This study was supported by the Science Foundation of Jiangsu Province for Institutions of Higher Learning (No. 08kjb320004).

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    Graphical Abstract
    • Abstract
  • Regular use of aspirin (ASA) could reduce the risk of gastric cancer although the precise mechanism remains unclear. Down-regulation of survivin may be one of the cyclooxygenase-independent mechanisms whereby ASA induces apoptosis of gastric cancer cell. In this study, we investigated the effect of ASA on the growth, apoptosis and survivin expression of gastric cancer cell line SGC7901. The survival of cells treated with 3.0 and 10.0 mmol/L ASA for 24 h was decreased by 44.6% and 88.5%, respectively. ASA at 3.0 mmol/L inhibited the viability of SGC7901 cells in a time-dependent manner. Apoptosis analysis showed similar results with MTT assay. ASA at 3.0 and 10.0 mmol/L decreased the mRNA transcript levels of survivin and reduced survivin protein levels in SGC7901 cells also in a time-dependent manner. Our findings indicated that ASA inhibited the proliferation of SGC7901 by sup-pressing survivin at both the transcriptional and translational level.
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