
OB-Ala reduced sympathetic innervation of iBAT and POMC expression in the hypothalamus.
Figures of the Article
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OX2R agonist OB-Ala reduced energy expenditure and food intake.
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OB-Ala inhibited thermogenesis of brown adipose tissue.
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OX2R is selectively expressed in brown adipose tissue and does not affect white adipose tissue.
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OB-Ala reduced sympathetic innervation of iBAT and POMC expression in the hypothalamus.
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OB-Ala had no effect on thermogenic genes in primary brown adipocytes.
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OX2R is located at afferent nerve endings innervating brown adipose tissue.
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Intra-BAT infusion of OB-Ala inhibited iBAT thermogenesis during cold exposure.
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