• ISSN 1674-8301
  • CN 32-1810/R
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Xingxing Sun, Jun Wang, Qing Yan, Weizhu Ju, Fengxiang Zhang, Gang Yang, Kai Gu, Hailei Liu, Zidun wang, Xiaohong Jiang, Mingfang Li, Di Xu, Yi Xu, Hongwu Chen, Minglong Chen. Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220047
Citation: Xingxing Sun, Jun Wang, Qing Yan, Weizhu Ju, Fengxiang Zhang, Gang Yang, Kai Gu, Hailei Liu, Zidun wang, Xiaohong Jiang, Mingfang Li, Di Xu, Yi Xu, Hongwu Chen, Minglong Chen. Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220047

Epicardial adipose tissue around the superior vena cava: A single center study of factors related to atrial fibrillation

doi: 10.7555/JBR.36.20220047
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  • Corresponding author: Hongwu Chen and Yi Xu, Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China. Tel: +86-25-83717168, E-mails: chw2003_0_79@163.com and yixu@njmu.edu.cn
  • Received: 2022-03-13
  • Revised: 2022-05-08
  • Accepted: 2022-05-13
  • Published: 2022-06-20
  • The superior vena cava (SVC) is the main component of non-pulmonary vein (PV) ectopy in patients with atrial fibrillation (AF). Researchers have found that epicardial adipose tissue (EAT) volume is related to the AF substrate, which can be defined by the low voltage area (LVA). This study aimed to investigate the relationship between SVC-EAT and SVC-AF. Twenty-six patients with SVC-AF triggers were identified as the SVC-AF group. Other three groups were defined and included as the LVA-AF group (LVA>5%), non-LVA-AF group (LVA<5%), and physical examination (PE) group. EAT around left atrium (LA-EAT) and SVC-EAT volumes were obtained using a cardiac risk assessment module. According to the SVC/LA-EAT ratio, there are significant differences between the SVC-AF group and the three control groups (the SVC-AF group 0.092±0.041 vs. the LVA-AF group 0.054±0.026, the non-LVA-AF group 0.052±0.022, and the PE group 0.052±0.019, all P<0.001). Receiver operating characteristic curve analysis suggests the optimal cut-off point of SVC/LA-EAT ratio is 6.8% for detecting SVC-AF patients, with 81.1% sensitivity, 73.1% specificity, and an area under the curve of 0.83 (95% confidence interval, 0.75–0.91). Those with SVC-AF have a higher SVC/LA-EAT ratio and empirical SVC isolation could be considered if the SVC/LA-EAT ratio was over 6.8%.


  • CLC number: R541.75, Document code: A
    The authors reported no conflict of interests.
    △These authors contributed equally to this work.
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