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2022, 36(3): 167-180.

Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing .

Figures of the Article

Single cell transcriptional profiling of BALF cells.
Comparisons of the proportions of the 8 different BALF cell types between healthy controls and tuberculosis patients.
Different subclusters of alveolar macrophages identified in BALF cells.
Dot plot showing the expression of the top 3 marker genes in each macrophage subcluster across all 9 macrophage subclusters.
Functional enrichment analysis of macrophage subclusters that increased in active tuberculosis patients (subclusters 1–3, 6, and 7) with the upregulated differentially expressed genes.
Dot plot of M1-like and M2-like macrophage gene markers expression across the 9 macrophage subclusters.
Expression of the monocyte-like macrophage gene markers across the 9 macrophage subclusters.
UMAP plot of different macrophage subclusters colored by pseudo-temporal trajectory analysis.
Intercellular communications between macrophages and other cell types in tuberculosis patients and healthy controls.
Multilayer intercellular and intracellular signal networks among different macrophage subclusters.

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