Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review

Gaochen Lu; Quan Wen; Bota Cui; Qianqian Li; Faming Zhang

doi:10.7555/JBR.36.20220088

Volume 37 Issue 1

Jan. 2023

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The Journal of Biomedical Research > 2023 > 37(1): 69-76. > DOI: 10.7555/JBR.36.20220088

Gaochen Lu, Quan Wen, Bota Cui, Qianqian Li, Faming Zhang. Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review[J]. The Journal of Biomedical Research, 2023, 37(1): 69-76. DOI: 10.7555/JBR.36.20220088

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Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: The first case report and narrative review

Gaochen Lu^{1, 2},
Quan Wen^{1, 2},
Bota Cui^{1, 2},
Qianqian Li^{1, 2},
Faming Zhang^{1, 2, 3, 4, ,}

1.
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China
2.
Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, Jiangsu 210011, China
3.
Department of Microbiotherapy, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China
4.
National Clinical Research Center for Digestive Diseases, Xi'an, Shanxi 710032, China

Funds: This study was funded by the National Natural Science Foundation of China (Grant No. 81873548) and the Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine.

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Corresponding author:
Faming Zhang, Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing, Jiangsu 210011, China. Tel: +86-25-56662093, E-mail: fzhang@njmu.edu.cn
Received Date: April 16, 2022
Revised Date: May 23, 2022
Accepted Date: May 26, 2022
Available Online: June 27, 2022

Graphical Abstract

Abstract

Abstract

Amyotrophic lateral sclerosis (ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, and has an average survival time of three to five years. Growing evidence has suggested a bidirectional link between gut microbiota and neurodegeneration. Here we aimed to report one female case with ALS, who benefited from washed microbiota transplantation (WMT), an improved fecal microbiota transplantation (FMT), through a transendoscopic enteral tube during a 12-month follow-up. Notedly, the accidental scalp trauma the patient suffered later was treated with prescribed antibiotics that caused ALS deterioration. The subsequent rescue WMTs successfully stopped the progression of the disease with a quick improvement. The plateaus and reversals occurred during the whole course of WMT. The stool and blood samples from the first WMT to the last were collected for dynamic microbial and metabolomic analysis. We observed the microbial and metabolomic changing trend consistent with the disease status. This case report for the first time shows the direct clinical evidence on using WMT for treating ALS, indicating that WMT may be the novel treatment strategy for controlling this so-called incurable disease.
- fecal microbiota transplant,
- microbiome,
- efficacy,
- neurodegeneration,
- amyotrophic lateral sclerosis

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References (23)

References

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