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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 34 Issue 1
Jan.  2020
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Park Ho-Eun, Do Kyung-Hyo, Lee Wan-Kyu. The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells[J]. The Journal of Biomedical Research, 2020, 34(1): 36-43. DOI: 10.7555/JBR.33.20190095
Citation: Park Ho-Eun, Do Kyung-Hyo, Lee Wan-Kyu. The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells[J]. The Journal of Biomedical Research, 2020, 34(1): 36-43. DOI: 10.7555/JBR.33.20190095
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The immune-modulating effects of viable Weissella cibaria JW15 on RAW 264.7 macrophage cells

  • College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea

Funds: This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited
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  • Corresponding author:

    Wan-Kyu Lee, Laboratory of Veterinary Bacteriology, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea. Tel/Fax: +82-43-261-2960/+82-43-267-2595, E-mail: wklee@cbu.ac.kr

  • Received Date: June 27, 2019
  • Revised Date: August 13, 2019
  • Accepted Date: September 18, 2019
  • Available Online: November 27, 2019
    Graphical Abstract
    • Abstract
  • The objective of this study is to investigate the immune-enhancing ability of viable and heat-killed Weissella cibaria JW15 (JW15) isolated from Kimchi in RAW 264.7 macrophages. The immune effects were evaluated by measuring the production of NO, cytokines, inflammatory enzyme, and activation of NF-κB. Viable JW15 executed higher activity on stimulating the release of TNF-α as well as activating NF-κB compared to that of heat-killed JW15. Additionally, viable and heat-killed JW15 significantly increased the production of NO, IL-6 and TNF-α more than that of Lactobacillus rhamnosus GG (LGG). Furthermore, viable JW15 induced higher production of iNOS compared with that of viable LGG. Collectively, our finding indicates that viable JW15 had similar, if not more, immune-enhancing activities as heat-killed JW15. In addition, viable JW15 had higher immune-enhancing activity than commercial strain LGG. Therefore, viable JW15 has the potential to be used as a functional food to improve the host immune response.
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