3.8

CiteScore

2.4

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 34 Issue 4
Jul.  2020
Turn off MathJax
Article Contents
Abstract
References
Related Articles
Zheng Yuming, Jin Chaoling, Cui Huijuan, Dai Haojie, Yan Jue, Han Pingping, Hsu Bailing. Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT[J]. The Journal of Biomedical Research, 2020, 34(4): 309-317. DOI: 10.7555/JBR.33.20190004
Citation: Zheng Yuming, Jin Chaoling, Cui Huijuan, Dai Haojie, Yan Jue, Han Pingping, Hsu Bailing. Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT[J]. The Journal of Biomedical Research, 2020, 34(4): 309-317. DOI: 10.7555/JBR.33.20190004
shu

Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT

  • 1.

    Nuclear Medicine Department

  •  2.

    Oncology of Integrative Medicine Department, China-Japan Friendship Hospital, Beijing 100029, China

  • 3.

    Nuclear Medicine Department, Danli Hospital, Beijing 100073, China

  • 4.

    Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO 65201, USA

More Information
  • Corresponding author:

    Pingping Han, Nuclear Medicine Department, China-Japan Friendship Hospital, Beijing 100029, China. Tel: +86-010-84205508, E-mail: hanjiangpingping@163.com

    Bailing Hsu, Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO 65201, USA. Tel: +1-573-882-8201, E-mail: bailinghsu@gmail.com

  • Received Date: January 03, 2019
  • Revised Date: May 20, 2019
  • Accepted Date: June 03, 2019
  • Available Online: August 15, 2019
    Abstract
  • Currently, 18F-FDG coincidence SPECT (Co-SPECT)/CT scan still serves as an important tool for diagnosis, staging, and evaluation of cancer treatment in developing countries. We implemented full physical corrections (FPC) to Co-SPECT (quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image quantitation. FPC included attenuation, scatter, resolution recovery, and noise reduction. A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image performance. Subsequently, 15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18F-FDG Co-SPECT/CT scan followed by a 18F-FDG PET/CT scan. Functional parameters as SUVmax, SUVmean, SULpeak, and MTV from both quantitative Co-SPECT and PET were analyzed. Image resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm (17 mm for PET). The image contrast was enhanced from 1.7 to 6.32 (6.69 for PET) with slightly degraded uniformity in background (3.1% vs. 6.7%) (5.6% for PET). Patients' SUVmax, SUVmean, SULpeak, and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET (r=0.82–0.88). Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET (r=0.81–0.88). Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT.
    • FullText(HTML)
    • References (20)
  • [1]
    Facey K, Bradbury I, Laking G, et al. Overview of the clinical effectiveness of positron emission tomography imaging in selected cancers[J]. Health Technol Assess, 2007, 44(11): iii-iv, xi–267.
    [2]
    Gallamini A, Zwarthoed C, Borra A. Positron emission tomography (PET) in oncology[J]. Cancers, 2014, 6(4): 1821–1889. doi: 10.3390/cancers6041821
    [3]
    Ben-Haim S, Ell P. 18F-FDG PET and PET/CT in the evaluation of cancer treatment response[J]. J Nucl Med, 2009, 50(1): 88–99.
    [4]
    Martin WH, Delbeke D, Patton JA, et al. FDG-SPECT: correlation with FDG-PET[J]. J Nucl Med, 1995, 36(6): 988–995.
    [5]
    Martin WH, Delbeke D, Patton JA, et al. Detection of malignancies with SPECT versus PET, with 2-[fluorine-18] fluoro-2-deoxy-D-glucose[J]. Radiology, 1996, 198(1): 225–231. doi: 10.1148/radiology.198.1.8539384
    [6]
    Delbeke D, Patton JA, Martin WH, et al. FDG PET and dual-head gamma camera positron coincidence detection imaging of suspected malignancies and brain disorders[J]. J Nucl Med, 1999, 40(1): 110–117.
    [7]
    Qiao WL, Zhao JH, Wang C, et al. Comparison of 18F-FDG coincidence SPECT imaging and computed tomography in the initial staging and therapeutic evaluation of lymphomas[J]. Chin J Oncol (in Chinese), 2007, 29(7): 536–539.
    [8]
    Mao YS, He J, Zheng R, et al. The role of 18F-FDG DHC SPECT-CT in the diagnosis and staging for lung cancer[J]. Chin J Oncol (in Chinese), 2008, 30(12): 933–936.
    [9]
    Seo Y, Mari C, Hasegawa BH. Technological development and advances in single-photon emission computed tomography/computed tomography[J]. Semin Nucl Med, 2008, 38(3): 177–198. doi: 10.1053/j.semnuclmed.2008.01.001
    [10]
    Barret O, Carpenter TA, Clark JC, et al. Monte Carlo simulation and scatter correction of the GE Advance PET scanner with SimSET and Geant4[J]. Phys Med Biol, 2005, 50(20): 4823–4840. doi: 10.1088/0031-9155/50/20/006
    [11]
    Watson PG, Mainegra-Hing E, Tomic N, et al. Implementation of an efficient Monte Carlo calculation for CBCT scatter correction: phantom study[J]. J Appl Clin Med Phys, 2015, 16(4): 216–227. doi: 10.1120/jacmp.v16i4.5393
    [12]
    Sureau FC, Reader AJ, Comtat C, et al. Impact of image-space resolution modeling for studies with the high-resolution research tomograph[J]. J Nucl Med, 2008, 49(6): 1000–1008. doi: 10.2967/jnumed.107.045351
    [13]
    Rahmim A, Qi JY, Sossi V. Resolution modeling in PET imaging: theory, practice, benefits, and pitfalls[J]. Med Phys, 2013, 40(6): 064301.
    [14]
    Hsu B, Hu LH, Yang BH, et al. SPECT myocardial blood flow quantitation toward clinical use: a comparative study with 13N-Ammonia PET myocardial blood flow quantitation[J]. Eur J Nucl Med Mol Imaging, 2017, 44(1): 117–128. doi: 10.1007/s00259-016-3491-5
    [15]
    Gong K, Cherry SR, Qi JY. On the assessment of spatial resolution of PET systems with iterative image reconstruction[J]. Phys Med Biol, 2016, 61(5): N193–N202. doi: 10.1088/0031-9155/61/5/N193
    [16]
    Melcher CL. Scintillation crystals for PET[J]. J Nucl Med, 2000, 41(6): 1051–1055.
    [17]
    Bettinardi V, Mancosu P, Danna M, et al. Two-dimensional vs three-dimensional imaging in whole body oncologic PET/CT: a Discovery-STE phantom and patient study[J]. Q J Nucl Med Mol Imaging, 2007, 51(3): 214–223.
    [18]
    Tanaka E, Hasegawa T, Yamashita T, et al. A 2D/3D hybrid PET scanner with rotating partial slice-septa and its quantitative procedures[J]. Phys Med Biol, 2000, 45(10): 2821–2841. doi: 10.1088/0031-9155/45/10/307
    [19]
    Surti S. Update on time-of-flight PET imaging[J]. J Nucl Med, 2015, 56(1): 98–105. doi: 10.2967/jnumed.114.145029
    [20]
    El Fakhri G, Surti S, Trott CM, et al. Improvement in lesion detection with whole-body oncologic time-of-flight PET[J]. J Nucl Med, 2011, 52(3): 347–353. doi: 10.2967/jnumed.110.080382
    • Related Articles

  • Related Articles

    [1]Natalia V. Naryzhnaya, Leonid N. Maslov, Sergey V. Popov, Alexandr V. Mukhomezyanov, Vyacheslav V. Ryabov, Boris K. Kurbatov, Alexandra E. Gombozhapova, Nirmal Singh, Feng Fu, Jian-Ming Pei, Sergey V. Logvinov. Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy[J]. The Journal of Biomedical Research, 2022, 36(6): 375-389. DOI: 10.7555/JBR.36.20220123
    [2]Yong-Dae Kim, Dong-Hyuk Yim, Sang-Yong Eom, Ji Yeoun Lee, Heon Kim. The effect of sunblock against oxidative stress in farmers: a pilot study[J]. The Journal of Biomedical Research, 2017, 31(4): 344-349. DOI: 10.7555/JBR.31.20160092
    [3]Iyaswamy Ashok, Rathinasamy Sheeladevi, Dapkupar Wankhar. Acute effect of aspartame-induced oxidative stress in Wistar albino rat brain[J]. The Journal of Biomedical Research, 2015, 29(5): 390-396. DOI: 10.7555/JBR.28.20120118
    [4]Xiaofan Yang, Bin Sun, Huijuan Wang, Cheng Yin, Xiaole Wang, Xiaohui Ji. Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling[J]. The Journal of Biomedical Research, 2015, 29(3): 232-240. DOI: 10.7555/JBR.29.20130037
    [5]Lintao Wang, Yanyan Peng, Kaikai Shi, Haixiao Wang, Jianlei Lu, Yanli Li, Changyan Ma. Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis[J]. The Journal of Biomedical Research, 2015, 29(2): 132-138. DOI: 10.7555/JBR.27.20120115
    [6]Pengpeng Jin, Xiaoli Wang, Fei Chang, Yinyang Bai, Yingchun Li, Rong Zhou, Ling Chen. Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats[J]. The Journal of Biomedical Research, 2013, 27(2): 135-144. DOI: 10.7555/JBR.27.20120076
    [7]Yan Li, Yi Jiang, Yicong Wan, Lin Zhang, Weiwei Tang, Jingjing Ma, Shan Wu, Wenjun Cheng. Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway[J]. The Journal of Biomedical Research, 2013, 27(1): 43-50. DOI: 10.7555/JBR.27.20120051
    [8]Danyang Ren, Quan Zhu, Jiantao Li, Tuanzhu Ha, Xiaohui Wang, Yuehua Li. Overexpression of angiopoietin-1 reduces doxorubicin-induced apoptosis in cardiomyocytes[J]. The Journal of Biomedical Research, 2012, 26(6): 432-438. DOI: 10.7555/JBR.26.20120006
    [9]Xiaozheng Zhong, Xiaoyu Li, Lingling Qian, Yiming Xu, Yan Lu, Jing Zhang, Nan Li, Xudong Zhu, Jingjing Ben, Qing Yang, Qi Chen. Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats[J]. The Journal of Biomedical Research, 2012, 26(5): 346-354. DOI: 10.7555/JBR.26.20110124
    [10]Lingyun Li, Jing Chi, Feng Zhou, Dandan Guo, Fang Wang, Genyan Liu, Chun Zhang, Kun Yao. Human herpesvirus 6A induces apoptosis of HSB-2 cells via a mitochondrion-related caspase pathway[J]. The Journal of Biomedical Research, 2010, 24(6): 444-451. DOI: 10.1016/S1674-8301(10)60059-0

Catalog

    Corresponding author: Hsu Bailing, bailinghsu@gmail.com
    • 4.

      Nuclear Science and Engineering Institute, University of Missouri-Columbia, Columbia, MO 65201, USA

    1. On this Site
    2. On Google Scholar
    3. On PubMed
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2959) PDF downloads (48) Cited by()
    Related

    ©2025 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return