4.6

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2.2

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  • ISSN 1674-8301
  • CN 32-1810/R
Lei Chang, Chun-Yu Yin, Hai-Yin Wu, Bin-Bin Tian, Yan Zhu, Chun-Xia Luo, Dong-YaZhu. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines[J]. The Journal of Biomedical Research, 2017, 31(4): 306-314. DOI: 10.7555/JBR.31.20160138
Citation: Lei Chang, Chun-Yu Yin, Hai-Yin Wu, Bin-Bin Tian, Yan Zhu, Chun-Xia Luo, Dong-YaZhu. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines[J]. The Journal of Biomedical Research, 2017, 31(4): 306-314. DOI: 10.7555/JBR.31.20160138

(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines

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This work was supported by grants from National Natural Science Foundation of China (91232304, 31530091, 81571188 and 81222016), the Natural Science Foundation of Jiangsu Province (BK2011029) and Distinguished Young Scientists Fund (BK20130040), and the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine

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  • Received Date: November 22, 2016
  • Revised Date: December 07, 2016
  • Stroke is one of the leading causes of disability and death globally. It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue. (+)-Borneol, a simple bicyclic monoterpene extracted from traditional Chinese medicine, is widely used in various types of diseases. However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. Here, we report that in the rat model of permanent cerebral ischemia, we found that (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scores via reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-a) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. These findings suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke.
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    1. Xu C, Mei Y, Yang R, et al. Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis. Cell Biosci, 2024, 14(1): 55. DOI:10.1186/s13578-024-01230-8
    2. Tan X, Zhang K, Shi W, et al. Research progress on the regulation and mechanism of borneol on the blood-brain barrier in pathological states: a narrative review focused on ischemic stroke and cerebral glioma. Transl Cancer Res, 2023, 12(11): 3198-3209. DOI:10.21037/tcr-23-1487
    3. Wang Y, Qiu XY, Liu JY, et al. (+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission. Acta Pharmacol Sin, 2023, 44(8): 1600-1611. DOI:10.1038/s41401-023-01075-w
    4. Zhang W, Yang H, Gao M, et al. Edaravone Dexborneol Alleviates Cerebral Ischemic Injury via MKP-1-Mediated Inhibition of MAPKs and Activation of Nrf2. Biomed Res Int, 2022, 2022: 4013707. DOI:10.1155/2022/4013707
    5. Huang P, Wan H, Shao C, et al. Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury. Front Pharmacol, 2022, 12: 688596. DOI:10.3389/fphar.2021.688596
    6. Li Y, Ren M, Wang J, et al. Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review. Front Pharmacol, 2021, 12: 606682. DOI:10.3389/fphar.2021.606682
    7. da Fonsêca DV, da Silva Maia Bezerra Filho C, Lima TC, et al. Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy. Biomolecules, 2019, 9(12): 835. DOI:10.3390/biom9120835
    8. Peng T, Jiang Y, Farhan M, et al. Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy. Front Pharmacol, 2019, 10: 204. DOI:10.3389/fphar.2019.00204
    9. Abdel-Fattah MM, Messiha BAS, Mansour AM. Modulation of brain ACE and ACE2 may be a promising protective strategy against cerebral ischemia/reperfusion injury: an experimental trial in rats. Naunyn Schmiedebergs Arch Pharmacol, 2018, 391(9): 1003-1020. DOI:10.1007/s00210-018-1523-3
    10. Lu X, Gu R, Hu W, et al. Upregulation of heme oxygenase-1 protected against brain damage induced by transient cerebral ischemia-reperfusion injury in rats. Exp Ther Med, 2018, 15(6): 4629-4636. DOI:10.3892/etm.2018.6049

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