4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 6
Oct.  2012
Turn off MathJax
Article Contents
Abstract
Zhida Sun, Rong Zhang, Huijuan Wang, Pengtao Jiang, Jiangquan Zhang, Mingshun Zhang, Lei Gu, Xiaofan Yang, Miaojia Zhang, Xiaohui Ji. Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells[J]. The Journal of Biomedical Research, 2012, 26(6): 456-466. DOI: 10.7555/JBR.26.20120115
Citation: Zhida Sun, Rong Zhang, Huijuan Wang, Pengtao Jiang, Jiangquan Zhang, Mingshun Zhang, Lei Gu, Xiaofan Yang, Miaojia Zhang, Xiaohui Ji. Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells[J]. The Journal of Biomedical Research, 2012, 26(6): 456-466. DOI: 10.7555/JBR.26.20120115
shu

Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells

  • 1.

    Department of Oral Mucosal Diseases, the Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 2.

    Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 3.

    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 4.

    Department of Rheumatology, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds: 

Science Research Foundation of Ministry of Education of China (No. 205057) and Foundation of Jiangsu Province Natural Science (No. 2004148)

More Information
  • Received Date: October 08, 2011
    Graphical Abstract
    • Abstract
  • The role played by cytokines, other than interferon (IFN)-α, in the differentiation and function of dendritic cells (DCs) in systemic lupus erythematosus (SLE), remains unclear. Serum interleukin-10 (IL-10) levels are generally elevated in SLE patients, which might modulate the differentiation of DCs. In this study, DCs were induced from monocytes either by transendothelial trafficking or by culture with granulocyte-macrophage colony-stimulating factor (GM-CSF) + IL-4 + tumor necrosis factor (TNF)-α. Both systems were used to investigate the effects of elevated serum IL-10 level on DC differentiation in SLE patients. The results showed that monocyte-derived DCs induced by either SLE serum or exogenous IL-10 reduced the expression of human leukocyte antigen (HLA)-DR and CD80, decreased IL-12p40 level, and increased IL-10 level, and exhibited an impaired capacity to stimulate allogenic T-cell proliferation. These results indicate that serum IL-10 may be involved in the pathogenesis of SLE by modulating the differentiation and function of DCs.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Cited by

    Periodical cited type(16)

    1. Liu Y, Zhang X, Xiao C, et al. Engineered hydrogels for peripheral nerve repair. Mater Today Bio, 2023, 20: 100668. DOI:10.1016/j.mtbio.2023.100668
    2. Zhou H, He Y, Xiong W, et al. MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases. Bioact Mater, 2022, 23: 409-437. DOI:10.1016/j.bioactmat.2022.11.007
    3. Wang H, Wang F, Wang Y, et al. Study on the Mechanism of BMSCs in Regulating NF-κB Signal Pathway by Targeting miR-449a to Improve the Inflammatory Response to Peripheral Nerve Injury. J Musculoskelet Neuronal Interact, 2022, 22(4): 546-561.
    4. Sun Q, Li G, Liu D, et al. Peripheral nerves in the tibial subchondral bone: the role of pain and homeostasis in osteoarthritis. Bone Joint Res, 2022, 11(7): 439-452. DOI:10.1302/2046-3758.117.BJR-2021-0355.R1
    5. Chen JT, Schmidt L, Schürger C, et al. Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury. Int J Mol Sci, 2021, 22(18): 10090. DOI:10.3390/ijms221810090
    6. Wan QQ, Qin WP, Ma YX, et al. Crosstalk between Bone and Nerves within Bone. Adv Sci (Weinh), 2021, 8(7): 2003390. DOI:10.1002/advs.202003390
    7. Ding S, Guo X, Zhu L, et al. Macrophage-derived netrin-1 contributes to endometriosis-associated pain. Ann Transl Med, 2021, 9(1): 29. DOI:10.21037/atm-20-2161
    8. Gao R, Peng X, Perry C, et al. Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. J Clin Invest, 2021, 131(1): e136542. DOI:10.1172/JCI136542
    9. Dun XP, Parkinson DB. Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration. Neural Regen Res, 2020, 15(1): 6-9. DOI:10.4103/1673-5374.264441
    10. Karamzadeh T, Alipour H, Shahriari-Namadi M, et al. Molecular characterization of the netrin-1 UNC-5 receptor in Lucilia sericata larvae. AIMS Genet, 2019, 6(3): 46-54. DOI:10.3934/genet.2019.3.46
    11. Ko SY, Price JT, Blatch GL, et al. Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon. J Histochem Cytochem, 2019, 67(5): 335-349. DOI:10.1369/0022155418819821
    12. Huang CW, Huang WC, Qiu X, et al. The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration. Sci Rep, 2017, 7(1): 17401. DOI:10.1038/s41598-017-17043-4
    13. Dun XP, Parkinson DB. Role of Netrin-1 Signaling in Nerve Regeneration. Int J Mol Sci, 2017, 18(3): 491. DOI:10.3390/ijms18030491
    14. Prieto CP, Ortiz MC, Villanueva A, et al. Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton's jelly mesenchymal stem cells (WJ-MSC). Stem Cell Res Ther, 2017, 8(1): 43. DOI:10.1186/s13287-017-0494-5
    15. Lee SS, Lee SJ, Lee SH, et al. Netrin-1-Induced Stem Cell Bioactivity Contributes to the Regeneration of Injured Tissues via the Lipid Raft-Dependent Integrin α6β4 Signaling Pathway. Sci Rep, 2016, 6: 37526. DOI:10.1038/srep37526
    16. Li S, Hua Y, Jin J, et al. Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population. Oncotarget, 2016, 7(18): 25470-7. DOI:10.18632/oncotarget.8330

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (4569) PDF downloads (1356) Cited by(16)
    Related

    ©2023 by the Editorial Department of the Journals of Nanjing Medical University. All rights reserved.   苏ICP备05071376号-5

    Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail: info@rhhz.net  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return