4.6

CiteScore

2.2

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Vijayakumar Subramaniyan, Ramesh Venkatachalam, Prabhu Srinivasan, Manogar Palani. In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever[J]. The Journal of Biomedical Research, 2018, 32(3): 222-236. DOI: 10.7555/JBR.31.20160109
Citation: Vijayakumar Subramaniyan, Ramesh Venkatachalam, Prabhu Srinivasan, Manogar Palani. In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever[J]. The Journal of Biomedical Research, 2018, 32(3): 222-236. DOI: 10.7555/JBR.31.20160109

In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever

Funds: 

The authors are grateful to the DST-SERB (SB/YS/ LS-109/2014) for providing financial assistance in this project. We specially express our thanks to the management of A.V.V.M. Sri Pushpam College (Autonomous), Poondi, for providing them necessary facilities and support to carry out this work.

More Information
  • Received Date: August 31, 2016
  • Revised Date: August 03, 2017
  • Reverse vaccinology method was used to predict the monovalent peptide vaccine candidate to produce antibodies for therapeutic purpose and to predict tetravalent vaccine candidate to act as a common vaccine to cover all the dengue virus serotypes. Envelope (E)-proteins of DENV-1-4 serotypes were used for vaccine prediction using NCBI, Uniprot/Swissprot, Swiss-prot viewer, VaxiJen V2.0, TMHMM, BCPREDS, Propred-1, Propred and MHC Pred. Eproteins of DENV-1-4 serotypes were identified as antigen from which T cell epitopes, through B cell epitopes, were predicted to act as peptide vaccine candidates. Each selected T cell epitope of E-protein was confirmed to act as vaccine and to induce complementary antibody against particular serotype of dengue virus. Chimeric tetravalent vaccine was formed by the conjugation of four vaccines, each from four dengue serotypes to act as a common vaccine candidate for all the four dengue serotypes. It can be justifiably concluded that the monovalent 9-mer T cell epitope for each DENV serotype can be used to produce specific antibody against dengue virus and a chimeric common tetravalent vaccine candidate to yield a comparative vaccine to cover any of the four dengue virus serotype. This vaccine is expected to be highly immunogenic against dengue fever.
  • Related Articles

    [1]Yingzhou Tu, Sen Wang, Haoran Wang, Peiyao Zhang, Mengyu Wang, Cunming Liu, Chun Yang, Riyue Jiang. The role of perioperative factors in the prognosis of cancer patients: A coin has two sides[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240164
    [2]Rampes Sanketh, Ma Katie, Divecha Yasmin Amy, Alam Azeem, Ma Daqing. Postoperative sleep disorders and their potential impacts on surgical outcomes[J]. The Journal of Biomedical Research, 2020, 34(4): 271-280. DOI: 10.7555/JBR.33.20190054
    [3]Huan Liu, Shijiang Zhang, Yongfeng Shao, Xiaohu Lu, Weidong Gu, Buqing Ni, Qun Gu, Junjie Du. Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis[J]. The Journal of Biomedical Research, 2018, 32(6): 454-460. DOI: 10.7555/JBR.31.20170011
    [4]Minbo Zang, Qiao Zhou, Yunfei Zhu, Mingxi Liu, Zuomin Zhou. Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice[J]. The Journal of Biomedical Research, 2018, 32(6): 442-453. DOI: 10.7555/JBR.31.20170023
    [5]Kaibo Lin, Shikun Zhang, Jieli Chen, Ding Yang, Mengyi Zhu, Eugene Yujun Xu. Generation and functional characterization of a conditional Pumilio2 null allele[J]. The Journal of Biomedical Research, 2018, 32(6): 434-441. DOI: 10.7555/JBR.32.20170117
    [6]Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li. Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery[J]. The Journal of Biomedical Research, 2018, 32(6): 411-423. DOI: 10.7555/JBR.32.20160170
    [7]Christopher J. Danford, Zemin Yao, Z. Gordon Jiang. Non-alcoholic fatty liver disease: a narrative review of genetics[J]. The Journal of Biomedical Research, 2018, 32(6): 389-400. DOI: 10.7555/JBR.32.20180045
    [8]Zhaosheng Jin, Ka Chun Suen, Daqing Ma. Perioperative “remote” acute lung injury: recent update[J]. The Journal of Biomedical Research, 2017, 31(3): 197-212. DOI: 10.7555/JBR.31.20160053
    [9]Dominik Choromanski, Joel Frederick, George Michael Mckelvey, Hong Wang. Intraoperative patient information handover between anesthesia providers[J]. The Journal of Biomedical Research, 2014, 28(5): 383-387. DOI: 10.7555/JBR.28.20140001
    [10]Sundeep?S.?Tumber, Hong?Liu. Epidural abscess after multiple lumbar punctures for labour epidural catheter placement[J]. The Journal of Biomedical Research, 2010, 24(4): 332-335. DOI: 10.1016/S1674-8301(10)60046-2

Catalog

    Article Metrics

    Article views PDF downloads Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return