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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 26 Issue 4
Jun.  2012
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Lihong Chen, Lianxiang Li, Feng Chen, Dalin He. Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma[J]. The Journal of Biomedical Research, 2012, 26(4): 274-277. DOI: 10.7555/JBR.26.20110103
Citation: Lihong Chen, Lianxiang Li, Feng Chen, Dalin He. Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma[J]. The Journal of Biomedical Research, 2012, 26(4): 274-277. DOI: 10.7555/JBR.26.20110103
shu

Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma

  • 1.

    Department of Cancer Research/Key Laboratory of Environment and Gene Related to Diseases of Ministry of Education, Xi'an Jiaotong University, School of Medicine, Xi'an, Shaanxi 710061, China

  • 2.

    Department of Gynecology and Obstetrics, Shaanxi Provincial Peop

  • 3.

    Department of Gynecology and Obstetrics, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China

  • 4.

    Department of Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA

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  • Received Date: September 10, 2011
    Graphical Abstract
    • Abstract
  • We sought to investigate the significance of p53 expression for epithelial ovarian carcinoma. In this study, we used immunohistochemical method to investigate the expression patterns of p53 in different subtypes of epithelial ovarian carcinoma. We found that the expressions of p53 protein in epithelial ovarian cancer (pituita, serosity and intima) were 88.9%, 75% and 100%, respectively, while the recurrence rates among three cancer subtypes were significantly different (33.3%, 12.5% and 0%, respectively; P < 0.05). Compared with patients without lymph node metastasis, the expression of p53 in patients with lymph node metastasis was significantly strong (68.75% and 100%, respectively; P < 0.05). However, the recurrence rate in the patients with lymph node metastasis (40%) was higher than that without lymph node metastasis (6.25%, P < 0.05). The expressions of p53 protein in ovarian cancer between Ⅰ-Ⅱ (25%) stage and Ⅱ-Ⅳ stage (100%) were significantly different (P < 0.05), and the recur-rence rates between the two groups were significantly different (0% and 31.25%, respectively, P < 0.05). There-fore, p53 protein has an intimate relationship with the malignant degree and the prognosis of ovarian cancer.
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