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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 39 Issue 2
Mar.  2025
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Dandan Zheng, Xiya Zhang, Jia Xu, Shuwen Chen, Bin Wang, Xiaoqin Yuan. LncRNA LINC01503 promotes angiogenesis in colorectal cancer by regulating VEGFA expression via miR-342-3p and HSP60 binding[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240190
Citation: Dandan Zheng, Xiya Zhang, Jia Xu, Shuwen Chen, Bin Wang, Xiaoqin Yuan. LncRNA LINC01503 promotes angiogenesis in colorectal cancer by regulating VEGFA expression via miR-342-3p and HSP60 binding[J]. The Journal of Biomedical Research. DOI: 10.7555/JBR.38.20240190
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LncRNA LINC01503 promotes angiogenesis in colorectal cancer by regulating VEGFA expression via miR-342-3p and HSP60 binding

  • 1.

    Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 2.

    Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 3.

    Department of Clinical Medicine, First Clinical Medicine College, Nanjing Medical University, Nanjing, Jiangsu 210029, China

  • 4.

    Department of Gastroenterology, the Affiliated Changshu Hospital of Nantong University, Changshu No.2 People's Hospital, Suzhou, Jiangsu 215500, China

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  • Corresponding author:

    Xiaoqin Yuan, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Xuehai Building, Rm D509, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu 211166, China. E-mail: yuanxq@njmu.edu.cn

  • △These authors contributed equally to this work.

  • Received Date: July 04, 2024
  • Revised Date: October 10, 2024
  • Accepted Date: October 11, 2024
    Graphical Abstract
    • Abstract

  • Colorectal cancer (CRC) ranks among the top five most common malignant tumors worldwide and has a high mortality rate. Angiogenesis plays an important role in CRC progression; however, anti-angiogenesis therapy still has many limitations. Long non-coding RNAs (lncRNAs) participate in tumor progression by regulating vascular endothelial growth factor expression in metastatic CRC. Thus, targeting specific lncRNA may provide some new hope for anti-angiogenic strategies. Through analyzing data both from both clinical samples and The Cancer Genome Atlas database, we found that the lncRNA LINC01503 was specifically upregulated in CRC tissues, and was associated with tumor progression and a poor overall survival. We also demonstrated that LINC01503 enhanced the capacity of tube formation and migration of vascular endothelial cells, thus promoting CRC tumorigenesis by upregulating vascular endothelial growth factor A (VEGFA) expression in CRC cells. Mechanistically, LINC01503 promoted the expression of VEGFA by simultaneously regulating the stability of both the mRNA and VEGFA by binding to miR-342-3p and the chaperone HSP60. The upregulation of LINC01503 in CRC cells was attributed to the CREB-binding protein CBP/p300-mediated H3K27 acetylation of the LINC01503 promoter region. Taken together, our findings clarify the mechanism by which LINC01503 may promote CRC angiogenesis, implicating that LINC01503 may serve as a potential prognostic biomarker and therapeutic target for CRC.

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    CLC number: R735.3, Document code: A

    The authors reported no conflict of interests.

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