4.6
CiteScore
2.2
Impact Factor
- ISSN 1674-8301
- CN 32-1810/R
4.6
2.2
| Citation: |
Vishal P. Dubey, Varun P. Sureja, Dharmeshkumar B. Kheni. Efficacy evaluation of standardized Rheum rhaponticum root extract (ERr 731®) on symptoms of menopause: A systematic review and meta-analysis study[J]. The Journal of Biomedical Research, 2024, 38(3): 278-286. DOI: 10.7555/JBR.37.20230219
|
Menopause is characterized by various physical, mental and emotional symptoms. ERr 731® is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal symptoms. The current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731® supplementation in alleviating the severity of menopausal symptoms. In this review, we searched across three online databases up to March 2023, evaluated the quality of the included studies by the Physiotherapy Evidence Database scale, and assessed the risk of bias by the Cochrane Risk of Bias tool. We then performed a meta-analysis using RevMan software to estimate the pooled mean difference (MD). The study protocol was registered in the Prospective Register of Systematic Reviews (CRD42023416808). After screening and evaluation, we included four high-quality studies (a total of 390 participants; the ERr 731® group: 193 participants; the control group: 197 participants) in the meta-analysis. The results showed that ERr 731® supplementation significantly reduced the Menopause Rating Scale score (MD: –15.12; P < 0.001), compared with control therapy. Sensitivity analysis revealed no effect of individual studies on the overall pooled estimate or overall observed heterogeneity. The current review provides evidence that ERr 731® supplementation is effective in reducing menopause symptoms. Potential bias and high heterogeneity in the results warrant further clinical studies.
None.
This work received no funding from any source.
CLC number: R711, Document code: A
The authors reported no conflict of interests.
| [1] |
Cengiz H, Kaya C, Caypinar SS, et al. The relationship between menopausal symptoms and metabolic syndrome in postmenopausal women[J]. J Obstet Gynaecol, 2019, 39(4): 529–533. doi: 10.1080/01443615.2018.1534812
|
| [2] |
Kaya C, Cengiz H, Yeşil A, et al. The relation among steroid hormone levels, lipid profile and menopausal symptom severity[J]. J Psychosom Obstet Gynecol, 2017, 38(4): 284–291. doi: 10.1080/0167482X.2017.1321633
|
| [3] |
Nelson HD. Menopause[J]. Lancet, 2008, 371(9614): 760–770. doi: 10.1016/S0140-6736(08)60346-3
|
| [4] |
Kalhan M, Singhania K, Choudhary P, et al. Prevalence of menopausal symptoms and its effect on quality of life among rural middle aged women (40-60 years) of Haryana, India[J]. Int J Appl Basic Med Res, 2020, 10(3): 183–188. doi: 10.4103/ijabmr.IJABMR_428_19
|
| [5] |
Shah J, Chandanani S, Reddy J, et al. Evaluation of the efficacy and safety of Rheum rhaponticum root extract (ERr 731) for menopausal symptoms in perimenopausal Indian women: An interim analysis[J]. J Midlife Health, 2021, 12(2): 108–115. https://pubmed.ncbi.nlm.nih.gov/34526744/
|
| [6] |
Marjoribanks J, Farquhar C, Roberts H, et al. Long term hormone therapy for perimenopausal and postmenopausal women[J]. Cochrane Database Syst Rev, 2012, (7): CD004143. https://pubmed.ncbi.nlm.nih.gov/22786488/
|
| [7] |
Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy[J]. Arch Intern Med, 2001, 161(9): 1161–1172. doi: 10.1001/archinte.161.9.1161
|
| [8] |
Mehta J, Kling JM, Manson JE. Risks, benefits, and treatment modalities of menopausal hormone therapy: current concepts[J]. Front Endocrinol, 2021, 12: 564781. doi: 10.3389/fendo.2021.564781
|
| [9] |
Vollmer G, Papke A, Zierau O. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors[J]. Chin Med, 2010, 5: 7. doi: 10.1186/1749-8546-5-7
|
| [10] |
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews[J]. BMJ, 2021, 372: n71. doi: 10.1136/bmj.n71
|
| [11] |
Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions[M]. Hoboken: John Wiley & Sons, 2019: 156–167.
|
| [12] |
Dixon A, Robertson K, Yung A, et al. Efficacy of probiotics in patients of cardiovascular disease risk: a systematic review and meta-analysis[J]. Curr Hypertens Rep, 2020, 22(9): 74. doi: 10.1007/s11906-020-01080-y
|
| [13] |
Aguiar AF, Casonatto J. Effects of citrulline malate supplementation on muscle strength in resistance-trained adults: a systematic review and meta-analysis of randomized controlled trials[J]. J Diet Suppl, 2022, 19(6): 772–790. doi: 10.1080/19390211.2021.1939473
|
| [14] |
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials[J]. BMJ, 2019, 366: l4898. https://pubmed.ncbi.nlm.nih.gov/31462531/
|
| [15] |
Yagiz G, Akaras E, Kubis HP, et al. The effects of resistance training on architecture and volume of the upper extremity muscles: a systematic review of randomised controlled trials and meta-analyses[J]. Appl Sci, 2022, 12(3): 1593. doi: 10.3390/app12031593
|
| [16] |
Heger M, Ventskovskiy BM, Borzenko I, et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial[J]. Menopause, 2006, 13(5): 744–759. doi: 10.1097/01.gme.0000240632.08182.e4
|
| [17] |
Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, et al. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms[J]. Altern Ther Health Med, 2009, 15(1): 24–34. https://pubmed.ncbi.nlm.nih.gov/19161045/
|
| [18] |
Hasper I, Ventskovskiy BM, Rettenberger R, et al. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms[J]. Menopause, 2009, 16(1): 117–131. doi: 10.1097/gme.0b013e3181806446
|
| [19] |
Thiemann E, Heger PW, Chang JL, et al. The special extract ERr 731® is save in acute and long-term treatment of climacteric complaints in perimenopausal women[C]//Proceedings of the International Conference on Science and Society: Biopiracy and Phytomedicine. Mainz, Germany: ICSS, 2017: 49.
|
| [20] |
Jia M, Dahlman-Wright K, Gustafsson JÅ. Estrogen receptor alpha and beta in health and disease[J]. Best Pract Res Clin Endocrinol Metab, 2015, 29(4): 557–568. doi: 10.1016/j.beem.2015.04.008
|
| [21] |
Paterni I, Granchi C, Katzenellenbogen JA, et al. Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential[J]. Steroids, 2014, 90: 13–29. doi: 10.1016/j.steroids.2014.06.012
|
| [22] |
Chen GG, Zeng Q, Tse GMK. Estrogen and its receptors in cancer[J]. Med Res Rev, 2008, 28(6): 954–974. doi: 10.1002/med.20131
|
| [23] |
Brown M, Cato L, Jeselsohn R. Hormone-Responsive Cancers[M]//Strauss III JF, Barbieri RL. Yen & Jaffe's Reproductive Endocrinology. 8th ed. Amsterdam: Elsevier, 2019: 717–741. e8.
|
| [24] |
Wober J, Möller F, Richter T, et al. Activation of estrogen receptor-β by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds[J]. J Steroid Biochem Mol Biol, 2007, 107(3-5): 191–201. doi: 10.1016/j.jsbmb.2007.04.002
|
| [25] |
Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, et al. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women[J]. Menopause, 2007, 14(2): 270–283. doi: 10.1097/01.gme.0000251932.48426.35
|
| [26] |
Möller F, Richter T, Unger C, et al. Activation of estrogen receptor-ß by a special extract of Rheum rhaponticum (ERr 731®), its aglycones and structurally related compounds[J]. Zeitschrift für Phyther (in German), 2006, 27: 26. https://www.err731.com/?page_id=271
|
| [27] |
Papke A, Möller F, Rettenberger R, et al. The special extract of Rheum rhaponticum (ERr 731®) does not stimulate uterine growth and proliferation in ovariectomized wistar rats[J]. Zeitschrift für Phyther (in German), 2008, 29(S1): 28. doi: 10.1055/s-2008-1047875
|
| [28] |
Papke A, Kretzschmar G, Zierau O, et al. Effects of the special extract ERr 731® from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats[J]. J Steroid Biochem Mol Biol, 2009, 117(4-5): 176–184. doi: 10.1016/j.jsbmb.2009.09.011
|
| [29] |
Keiler AM, Papke A, Kretzschmar G, et al. Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats[J]. J Steroid Biochem Mol Biol, 2012, 128(1-2): 62–68. doi: 10.1016/j.jsbmb.2011.08.016
|
| [30] |
Kaszkin-Bettag M, Richardson A, Rettenberger R, et al. Long-term toxicity studies in dogs support the safety of the special extract ERr 731 from the roots of Rheum rhaponticum[J]. Food Chem Toxicol, 2008, 46(5): 1608–1618. doi: 10.1016/j.fct.2007.12.026
|
| [31] |
Kaszkin-Bettag M, Beck S, Richardson A, et al. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study[J]. Altern Ther Health Med, 2008, 14(6): 32–38. https://pubmed.ncbi.nlm.nih.gov/19043936/
|
| [32] |
Chang JL, Montalto MB, Heger PW, et al. Rheum rhaponticum extract (ERr 731): Postmarketing data on safety surveillance and consumer complaints[J]. Integr Med, 2016, 15(3): 34–39. https://pubmed.ncbi.nlm.nih.gov/27547165/
|
| 1. | Almas T, Nagarajan VR, Ahmed D, et al. Recurrent appendicitis of vermiform appendix after a prior appendectomy: A case report and review of the literature. Ann Med Surg (Lond), 2022, 77: 103603. DOI:10.1016/j.amsu.2022.103603 |
| 2. | Froiio C, Bernardi DT, Asti E, et al. Retroperitoneoscopic drainage of cryptogenic psoas abscess. BMJ Case Rep, 2020, 13(7): e235579. DOI:10.1136/bcr-2020-235579 |
| 3. | Kaneko G, Katsui M, Hattori S, et al. Laparoscopic management for a psoas abscess caused by migrated urolithiasis. IJU Case Rep, 2019, 2(5): 288-291. DOI:10.1002/iju5.12112 |
| 4. | Xu BY, Vasanwala FF, Low SG. A case report of an atypical presentation of pyogenic iliopsoas abscess. BMC Infect Dis, 2019, 19(1): 58. DOI:10.1186/s12879-019-3675-2 |
Figures(5) / Tables(4)
Supported by: Beijing Renhe Information Technology Co., Ltd. E-mail:
info@rhhz.net 
Authors and Reviewers
DownLoad: