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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 36 Issue 3
May  2022
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Ling Zhu, Jiawei Geng, An Xiao. Drug-induced severe liver injury due to Sterculia versicolor: a case report with causality assessment from possible to probable[J]. The Journal of Biomedical Research, 2022, 36(3): 215-220. DOI: 10.7555/JBR.36.20220044
Citation: Ling Zhu, Jiawei Geng, An Xiao. Drug-induced severe liver injury due to Sterculia versicolor: a case report with causality assessment from possible to probable[J]. The Journal of Biomedical Research, 2022, 36(3): 215-220. DOI: 10.7555/JBR.36.20220044
shu

Drug-induced severe liver injury due to Sterculia versicolor: a case report with causality assessment from possible to probable

  • Department of Infectious Diseases and Hepatic Diseases, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China

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  • Corresponding author:

    An Xiao and Jiawei Geng, Department of Infectious Diseases and Hepatic Diseases, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, 157 Jinbi Road, Kunming, Yunnan 650032, China. Tel/Fax: +86-871-63638520/+86-871-63638521 . E-mails: nh4no4@126.com and 617545329@qq.com

  • Received Date: March 10, 2022
  • Revised Date: April 03, 2022
  • Accepted Date: April 10, 2022
  • Available Online: May 27, 2022
    Abstract
  • Sterculia gum, the dry exudate of Sterculia versicolor and other members of the same genus, is used as a thickener and emulsifier in foods. It is generally considered safe as a food or drug, and its adverse reactions, such as Sterculia-induced liver injury, have never been reported. A 46-year-old woman was admitted to hospital with fatigue, nausea, abdominal distension, jaundice and a >16-fold increase in transaminase and bilirubin level. The patient had used Sterculia gum prior to the onset of her symptoms. Her symptoms and clinical indicators improved after treatment. The possibility of acute viral hepatitis, autoimmune hepatitis, and metabolic liver disease was excluded. After discharge from hospital, the patient had a severe liver injury again when re-exposed to Sterculia gum. And the Roussel Uclaf Causality Assessment Method score was updated from 5 to 7, which was consistent with probable drug-induced liver injury. This is the first report of Sterculia-induced liver injury. Clinicians need to be aware of the potential hepatotoxicity of Sterculia.
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    • References (10)
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    Corresponding author: An Xiao, nh4no4@126.com

    • Department of Infectious Diseases and Hepatic Diseases, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China

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