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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 37 Issue 2
Mar.  2023
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Lan Ma, Haiyan Chu, Meilin Wang, Zhengdong Zhang. Biological functions and potential implications of circular RNAs[J]. The Journal of Biomedical Research, 2023, 37(2): 89-99. DOI: 10.7555/JBR.36.20220095
Citation: Lan Ma, Haiyan Chu, Meilin Wang, Zhengdong Zhang. Biological functions and potential implications of circular RNAs[J]. The Journal of Biomedical Research, 2023, 37(2): 89-99. DOI: 10.7555/JBR.36.20220095
shu

Biological functions and potential implications of circular RNAs

  • 1.

    Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 2.

    Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China

More Information
  • Corresponding author:

    Zhengdong Zhang, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, Jiangsu 211166, China. Tel: +86-25-86868423, E-mail: drzdzhang@njmu.edu.cn

  • Received Date: April 26, 2022
  • Revised Date: August 17, 2022
  • Accepted Date: August 29, 2022
  • Available Online: October 27, 2022
    Graphical Abstract
    • Abstract
  • Circular RNAs (circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges, interacting with proteins, modulating the expression of related genes and translating into peptides or proteins. CircRNAs have also been used as biomarkers for a number of diseases, which could improve clinical practice. This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.
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  • CLC number: Q522, Document code: A

    The authors reported no conflict of interests.

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