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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 6
Nov.  2021
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Xue Geng, Meng Wang, Yunjun Leng, Lin Li, Haiyuan Yang, Yifan Dai, Ying Wang. Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation[J]. The Journal of Biomedical Research, 2021, 35(6): 474-490. DOI: 10.7555/JBR.35.20210107
Citation: Xue Geng, Meng Wang, Yunjun Leng, Lin Li, Haiyuan Yang, Yifan Dai, Ying Wang. Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation[J]. The Journal of Biomedical Research, 2021, 35(6): 474-490. DOI: 10.7555/JBR.35.20210107
shu

Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation

  • 1.

    Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, Jiangsu 211166, China

  • 2.

    Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China

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  • Corresponding author:

    Ying Wang, Haiyuan Yang, and Yifan Dai, Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China. Tel/Fax: +86-25-86869477, E-mails: ywang@njmu.edu.cn, hyyang@njmu.edu.cn, and daiyifan@njmu.edu.cn

  • Received Date: July 01, 2021
  • Revised Date: July 26, 2021
  • Accepted Date: August 05, 2021
  • Available Online: September 29, 2021
    Graphical Abstract
    • Abstract
  • Acute hypoxic-ischemic brain damage (HIBD) mainly occurs in adults as a result of perioperative cardiac arrest and asphyxia. The benefits of n-3 polyunsaturated fatty acids (n-3 PUFAs) in maintaining brain growth and development are well documented. However, possible protective targets and underlying mechanisms of mfat-1 mice on HIBD require further investigation. The mfat-1 transgenic mice exhibited protective effects on HIBD, as indicated by reduced infarct range and improved neurobehavioral defects. RNA-seq analysis showed that multiple pathways and targets were involved in this process, with the anti-inflammatory pathway as the most significant. This study has shown for the first time that mfat-1 has protective effects on HIBD in mice. Activation of a G protein-coupled receptor 120 (GPR120)-related anti-inflammatory pathway may be associated with perioperative and postoperative complications, thus innovating clinical intervention strategy may potentially benefit patients with HIBD.
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    • References (48)
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