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  • ISSN 1674-8301
  • CN 32-1810/R
Volume 35 Issue 5
Sep.  2021
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Zhang Weifeng, Chen Han, Zhang Guoxin, Jin Guangfu. A nomogram for predicting lymph node metastasis in superficial esophageal squamous cell carcinoma[J]. The Journal of Biomedical Research, 2021, 35(5): 361-370. DOI: 10.7555/JBR.35.20210034
Citation: Zhang Weifeng, Chen Han, Zhang Guoxin, Jin Guangfu. A nomogram for predicting lymph node metastasis in superficial esophageal squamous cell carcinoma[J]. The Journal of Biomedical Research, 2021, 35(5): 361-370. DOI: 10.7555/JBR.35.20210034
shu

A nomogram for predicting lymph node metastasis in superficial esophageal squamous cell carcinoma

  • 1.

    Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China

  • 2.

    The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 210000, China

  • 3.

    Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China

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  • Corresponding author:

    Guoxin Zhang, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, China. Tel: 13951913128, E-mail: guoxinz@njmu.edu.cn

    Guangfu Jin, Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Tel: 13851814935, E-mail: guangfujin@njmu.edu.cn

  • Received Date: February 27, 2021
  • Revised Date: May 20, 2021
  • Accepted Date: May 24, 2021
  • Available Online: August 02, 2021
    Graphical Abstract
    • Abstract
  • Superficial esophageal squamous cell carcinoma (SESCC) is defined as carcinoma with mucosal or submucosal invasion, regardless of regional lymph node metastasis (LNM). The lymph node status is not only a key factor to determine the training strategy, but also the most important prognostic factor in esophageal cancer. In this study, we establish a clinical nomogram for predicting LNM in patients with SESCC. A predictive model was established based on the training cohort composed of 711 patients who underwent esophagectomy for SESCC from December 2009 to June 2018. A prospective cohort of 203 patients from June 2018 to January 2019 was used for validation. Favorable calibration and well-fitted decision curve analysis were conducted and good discrimination was observed (concordance index [C-index], 0.860; 95% confidence interval [CI], 0.825–0.894) through internal validation. The external validation cohort presented good discrimination (C-index, 0.916; 95% CI, 0.860–0.971). This model may facilitate the prediction of LNM in patients with SESCCs.
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    • References (42)
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    1. Wang J, Zhang X, Gan T, et al. Risk factors and a predictive nomogram for lymph node metastasis in superficial esophageal squamous cell carcinoma. World J Gastroenterol, 2023, 29(47): 6138-6147. DOI:10.3748/wjg.v29.i47.6138

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